Results 101 to 110 of about 94,167 (304)

NUP85 Mediates Endoplasmic Reticulum Stress through the USP47/ASK1 Signaling Pathway to Regulate the Progression of Liver Fibrosis

Advanced Science, EarlyView.
In the present study, we have demonstrated that the NUP85‐USP47‐ASK1 signaling pathway may have regulated the progression of liver fibrosis through modulating ERS. Additionally, we have developed a CREKA‐coupled liposome to target delivery of MV, a pharmacological inhibitor of NUP85, to activated HSCs, thereby attenuating liver fibrosis. ABSTRACT Liver
Dashuai Yang, Haoran Yang, Linxin Pan, Chang Tian, Fucheng Zuo, Shilei Huang, Xianrui Li, Ming Chen, Cheng Qian, Jie Wang, Zhaolin Chen, Tao Xu   +11 more
wiley   +1 more source

Tumor‐Derived LAMB3 Drives Immunosuppressive LRRC15+ Fibroblast Formation During Pancreatic Ductal Adenocarcinoma Development

Advanced Science, EarlyView.
A single‐cell atlas of pancreatic ductal adenocarcinoma development reveals progressive ductal‐fibroblast‐immune crosstalk. Tumor‐derived LAMB3 drives the formation of immunosuppressive LRRC15+ fibroblasts through the ITGB1/FAK/MAPK/FOSL2 signaling. Glycolytic reprogramming upregulates LAMB3 and correlates with LRRC15+ fibroblast enrichment.
Xuqing Shi, Hangqi Liu, Jianru Sun, Xiaoding Liu, Xinping Jv, Longyun Chen, Yuhan Zhang, Hui Zhang, Xudong Xing, Ruiyu Li, Xinyi Ke, Jun Wang, Xianglin Yin, Bohan Liu, Qixian Liu, Yuan Wang, Junliang Lu, Shiyi Liu, Junyi Pang, Yumeng Cai, Menghua Dai, Fan Bai, Huanwen Wu, Zhiyong Liang   +23 more
wiley   +1 more source

Study on the key structure parameters of a gravity settling chamber based on a flow field simulation

Engineering Applications of Computational Fluid Mechanics, 2019
A gravity settling chamber plays an important role in improving the effect of the dust removal when it is selected as a dust collector in a pneumatic cleaning system for cleaning a subway tunnel. The settling rate and the indexes evaluating the secondary
Xiaojing Liu, Yicheng Zhang, Qiangyun Wu, Mingfeng Zhang, Fan Liu, Yuanchang Guo   +5 more
doaj   +1 more source

Differing cell surface distribution of human leukocyte antigen-DR molecules on epidermal Langerhans cells and eccrine duct cells.

, 1992
Scanning electron microscopy (SEM) with immunogold labeling was employed to observe the undersurface of the human epidermis after it was split from dermal connective tissue, in an attempt to localize the molecules actually expressed on cell/tissue ...
S Imayama, Y Hori, Y Yashima
core   +1 more source

Additional file 1 of Tubular bile duct structure mimicking bile duct morphogenesis for prospective in vitro liver metabolite recovery

, 2020
Additional file 1: Fig. S1. Optimum culture condition for bile duct structure establishment mimicking IHBD morphogenesis. a, In vitro bile duct-like development on polystyrene (TCPS) and PDMS plate.
Marie Shinohara (1429984), Minoru Tanaka (136513), Astia Rizki-Safitri (8597490), Yasuyuki Sakai (251679)   +3 more
core   +1 more source

Macrophage Extracellular Traps in Immunity and Cancer

Advanced Science, EarlyView.
As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li, Eugenie Nepovimova, Adam Grundel, Lukas Peter, Qinghua Wu, Kamil Kuca   +5 more
wiley   +1 more source

Unsteady Interaction Between a Transonic Turbine Stage and Downstream Components

International Journal of Rotating Machinery, 2004
Results from a numerical simulation of the unsteady flow through one quarter of the circumference of a transonic high-pressure turbine stage, transition duct, and low-pressure turbine first vane are presented and compared with experimental data. Analysis
Roger L. Davis, Jixian Yao, John P. Clark, Gary Stetson, Juan J. Alonso, Antony Jameson, Charles W. Haldeman, Michael G. Dunn   +7 more
doaj   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Impact of Mesoscale Eddies on Acoustic Propagation Under a Rough Sea Surface

Remote Sensing
This study investigates the combined effects of mesoscale eddies and rough sea surfaces on acoustic propagation in the eastern Arabian Sea and Gulf of Aden during summer monsoon conditions.
Shaoze Zhang, Jian Shi, Xuhui Cao
doaj   +1 more source

Leveraging Macrophage Metabolic Reprogramming for Enhanced Anti‐Tumor Immunity

Advanced Science, EarlyView.
Tumor‐associated macrophages (TAMs) are key regulators of the tumor microenvironment (TME), with their metabolic states playing a critical role in tumor progression or regression. This review summarizes current understanding of TAM metabolic plasticity alongside cutting‐edge bioengineering innovations, outlining a roadmap for transforming the ...
Zhiyun Liu, Lingyao Zeng, Xulin Gan, Yilin Zhou, Han Shen, Dan Wu, Xin Shou, Minmin Jiang, Liyun Shi   +8 more
wiley   +1 more source