Results 111 to 120 of about 11,072,047 (305)

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Revealing the electron transfer mechanism of defective carbon nitride during photocatalytic H2O2 production

Nano Research
Photosynthesis is a promising method for H2O2 production, but its application in pure water is limited by slow oxidation kinetics and rapid photocarrier recombination of photocatalysts.
Lixia Ma, Lu Zhang, Xiaojie Zhou, Jie Yang, Deng Li, Xuqian Zhao, Yinuo Su, Yu Chen, Zong-Huai Liu, Ruibin Jiang   +9 more
doaj   +1 more source

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

FEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo, Kátia Cristiane Hall, Matheus dos Santos Fernandez, Geovanna Peter Corrêa, Rafael Guerra Lund   +4 more
wiley   +1 more source

Atomic tuning of TixCr1−xN catalysts to enhance the polysulfide trapping and conversion in lithium–sulfur batteries

Nano Research
Lithium–sulfur (Li–S) batteries face critical challenges, including sluggish polysulfide redox kinetics and the shuttle effect. This study presents a novel self-supporting carbon nanofibers (CNFs) decorated with TixCr1−xN (TCN) solid–solution ...
Jiyuan Zhang, Weiye Zhang, Jiarui Xue, Nan Zhu, Yunping Ge, Zhibin Lei, Qi Li, Xuexia He, Zonghuai Liu, Jie Sun   +9 more
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Synergistic versatile bistriflimide salts in light-accelerated spiro-OMeTAD oxidation and perovskite module photovoltaics engineering

Nature Communications
2,2’,7,7-tetrakis(N,N-di(4-methoxyphenylamine)−9,9′-spirobifluorene (spiro-OMeTAD) remains as the most widely used  material for the hole transport layer (HTL) in efficient n-i-p perovskite photovoltaic devices.
Jiahao Zhang, Xiaomin Liu, Haifei Wang, Penghui Ji, Shuai Yuan, Hengyuan Wang, Ting Guo, Silvia Mariotti, Ilhem Nadia Rabehi, Xiaomin Huo, Tianhao Wu, Congyang Zhang, Chenfeng Ding, Liliia Moshniaha, Kirill Mitrofanov, Dominik Madea, Ryota Kabe, Dandan Song, Zheng Xu, Zhuangzhi Wu, Yun Li, Yixin Zhao, Tongle Bu, Guoqing Tong, Luis K. Ono, Yabing Qi   +25 more
doaj   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

The surface energy and the compressibility [PDF]

, 1990
This paper discusses the relationship between surface energy and compressibility as they relate to the nucleus.
Myers, W.D.
core