Results 101 to 110 of about 1,523,806 (318)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

A new method to characterize degradation of first surface aluminium reflectors [PDF]

, 2010
This paper reports the development of a new optical instrument capable of characterizing the aging process of enhanced first surface aluminum reflectors for concentrating solar power (CSP) application. Samples were exposed outdoors at different sites and
Pitz-Paal, Robert, Meyen, S., Pitz-Paal, R., Kennedy, C., Heller, P., Schmucker, M., Sutter, Florian, Sutter, F., Fernandez, Arantxa, Schmücker, Martin, Meyen, Stephanie, Fernandez-Garcia, A., Heller, Peter, Kennedy, Cheryl   +13 more
core  

Micrometeorological and morphological observations of surface hoar dynamics on a mountain snow cover [PDF]

, 2010
The formation, growth, and destruction of surface hoar crystals is an important feature of mountain snow covers as buried surface hoar layers are a frequent weak layer leading to unstable snowpacks.
C. Manes, C. Fierz, Lehning, Manes, Costantino, STOESSEL F, Lehning, M., GUALA M, Guala, M., M. Lehning, M, Manes, C., Fierz, C., FIERZ C, F. Stössel, M. Guala, Stossel, F., Lehning, Michael, Stoessel, F.   +17 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Enhanced hydrogen evolution reaction activity through samarium-doped nickel phosphide (Ni2P) electrocatalyst

Scientific Reports
Hydrogen evolution reaction (HER) stands out among conventional hydrogen production processes by featuring excellent advantages. However, the uncompetitive production cost due to the low energy efficiency has hindered its development, necessitating the ...
Ali Shahroudi, Sajjad Habibzadeh
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

An energy-balance model for debris-covered glaciers including heat conduction through the debris layer [PDF]

, 2010
Extensive covers of supraglacial debris are often present in glacier ablation areas, and it is essential to assess exactly how the debris affects glacier melt rates.
Brock, B.W., Reid, Tim, Ben W. Brock, Reid, T.D., Brock, Benjamin, Tim D. Reid   +5 more
core   +1 more source

Oxidation and mineralization rates of harmful organic chemicals in hydroxyl radical induced reactions

Ecotoxicology and Environmental Safety
In most of advanced oxidation processes (AOPs) used to destroy harmful organic chemicals in water/wastewater hydroxyl radical (•OH) reactions oxidize (increasing the oxygen/carbon ratio in the molecules) and mineralize (transforming them to inorganic ...
László Wojnárovits, Renáta Homlok, Krisztina Kovács, Anna Tegze, Erzsébet Takács   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Mechanisms for surface potential decay on fluorinated epoxy in high voltage DC applications [PDF]

, 2014
Epoxy resin has been extensively used for decades as an insulation material in high voltage transmission systems. However, this insulation material does suffer from bulk and surface charging when used as insulating spacer, mainly in high voltage DC ...
Z. An, Mohamad, A., Y. Zhang, An, Z., A. Mohamad, Chen, G., G. Chen, Zhang, Y.   +7 more
core   +1 more source