Results 81 to 90 of about 11,072,047 (305)
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Yunxia Zhang +9 more
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Under prolonged high‐voltage cycling, single‐crystalline Ni‐rich cathodes are prone to severe transition metal dissolution, irreversible phase transformations, and reduced structural stability, which significantly hinder their practical application ...
Youqi Chu +9 more
doaj +1 more source
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani +9 more
wiley +1 more source
Highlights An amine-salt-assisted solution crystallization strategy is developed to grow high-quality CsPbCl3 single crystals (SCs) with a size as large as 15 mm, the SCs exhibit a high carrier mobility-lifetime product, low trap density, and large ...
Yujia Jiang +16 more
doaj +1 more source
Surface state energy shifts by molecular adsorption : CO on clean and Na covered Cu(111)
Angle resolved photoelectron energy spectra recorded in the near UV show that the surface state 0.4 eV below EF of Cu(111) shifts to higher energy upon CO adsorption.
Walldén, L., Lindgren, S.Å., Paul, Jan
core +1 more source
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
Organic-inorganic hybrid halide perovskites have been emerged as promising candidates for X-ray detectors while toxicity and instability are known issues. Here, Zhang et al.
Yunxia Zhang +9 more
doaj +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Hydrogen evolution reaction (HER) stands out among conventional hydrogen production processes by featuring excellent advantages. However, the uncompetitive production cost due to the low energy efficiency has hindered its development, necessitating the ...
Ali Shahroudi, Sajjad Habibzadeh
doaj +1 more source

