Results 31 to 40 of about 154,945 (258)

Numerical Simulation of Flow Field, Bubble Distribution and Solidified Shell in Slab Mold under Different EMBr Conditions Assisted with High-Temperature Quantitative Velocity Measurement

Metals, 2022
The flow field, bubble distribution and solidified shell in slab mold are numerically simulated with large eddy simulation (LES) under different electromagnetic braking (EMBr) conditions, assisted with high-temperature quantitative velocity measurement ...
Yi Guo, Jian Yang, Yibo Liu, Wenyuan He, Changliang Zhao, Yanqiang Liu   +5 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Numerical simulation study on the drag reduction characteristics of grooves-microbubbles coupling surfaces

International Journal of Metrology and Quality Engineering
Surface drag reduction technologies can significantly reduce the resistance during ship navigation, enhancing speed, efficiency and adaptability under various operating conditions.
Li Tianjian, Yang Tianlong, Dong Qin, Sun Xizhi, Wu Tao, Xu Ziqi   +5 more
doaj   +1 more source

Effects of surface charge and boundary slip on time-periodic pressure-driven flow and electrokinetic energy conversion in a nanotube

Beilstein Journal of Nanotechnology, 2019
Time-periodic pressure-driven slip flow and electrokinetic energy conversion efficiency in a nanotube are studied analytically. The slip length depends on the surface charge density.
Mandula Buren, Yongjun Jian, Yingchun Zhao, Long Chang, Quansheng Liu   +4 more
doaj   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Wind Stress Effects on Drone‐Based Thermal Infrared Surface Velocimetry Measurements of Tidal Flow in an Estuary

Water Resources Research
We evaluate the effect of surface wind stress on remote velocimetry measurements of tidal flow by comparing these measurements to the bulk flow velocity measured by a co‐located acoustic velocity profiler in a tidal channel.
Evan T. Heberlein, Marc Mayes, Bryn E. Morgan, Kelly K. Caylor, Seth A. Schweitzer, Edwin A. Cowen   +5 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Optimization of the gas flow system in a selective laser melting chamber using numerical methods

Advances in Mechanical Engineering
A well-designed flow field is a key factor to improve the surface quality of products by removing spatter, which is often generated during the selective laser melting (SLM) process.
Zirong Zhou, Yongxing Li, Xiaoxuan Chen, Xin Shang, Kunzheng Gou, Lijuan Pang   +5 more
doaj   +1 more source