Results 51 to 60 of about 198,581 (309)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Numerical Simulation of Flow Field, Bubble Distribution and Solidified Shell in Slab Mold under Different EMBr Conditions Assisted with High-Temperature Quantitative Velocity Measurement

Metals, 2022
The flow field, bubble distribution and solidified shell in slab mold are numerically simulated with large eddy simulation (LES) under different electromagnetic braking (EMBr) conditions, assisted with high-temperature quantitative velocity measurement ...
Yi Guo, Jian Yang, Yibo Liu, Wenyuan He, Changliang Zhao, Yanqiang Liu   +5 more
doaj   +1 more source

High-speed flow with discontinuous surface catalysis [PDF]

, 2000
In a reacting gas flow both gas-phase chemical activity and surface catalysis can increase the rate of heat transfer from the gas to a solid surface. In particular, when there is a discontinuous change in the catalytic properties of the surface, there ...
Tutty, O.R., Roberts, G.T., Amaratunga, S.R.   +2 more
core   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Wind Stress Effects on Drone‐Based Thermal Infrared Surface Velocimetry Measurements of Tidal Flow in an Estuary

Water Resources Research
We evaluate the effect of surface wind stress on remote velocimetry measurements of tidal flow by comparing these measurements to the bulk flow velocity measured by a co‐located acoustic velocity profiler in a tidal channel.
Evan T. Heberlein, Marc Mayes, Bryn E. Morgan, Kelly K. Caylor, Seth A. Schweitzer, Edwin A. Cowen   +5 more
doaj   +1 more source

Short-term variability in Greenland Ice Sheet motion forced by time-varying meltwater inputs: implications for the relationship between subglacial drainage system behavior and ice velocity. [PDF]

, 2012
High resolution measurements of ice motion along a 120 km transect in a land-terminating section of the GrIS reveal short-term velocity variations (<1 day), which are forced by rapid variations in meltwater input to the subglacial drainage system from
Cowton, Thomas, Bartholomew, Ian, Nienow, Peter, Sole, A., Mair, Douglas, Mair, D., Sole, Andrew, King, Matt A., Cowton, T., Bartholomew, I., King, M.A., Nienow, P.   +11 more
core   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Optimization of the gas flow system in a selective laser melting chamber using numerical methods

Advances in Mechanical Engineering
A well-designed flow field is a key factor to improve the surface quality of products by removing spatter, which is often generated during the selective laser melting (SLM) process.
Zirong Zhou, Yongxing Li, Xiaoxuan Chen, Xin Shang, Kunzheng Gou, Lijuan Pang   +5 more
doaj   +1 more source

High-resolution hot-film measurement of surface heat flux to an impinging jet [PDF]

, 2011
To investigate the complex coupling between surface heat transfer and local fluid velocity in convective heat transfer, advanced techniques are required to measure the surface heat flux at high spatial and temporal resolution.
T S O'Donovan, O'Donovan, T. S.; id_orcid, D B Murray, Murray, D. B., T Persoons, Persoons, T.   +5 more
core   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source