Results 41 to 50 of about 8,188,001 (252)

Natural Killer Cells in Paediatric Soft Tissue Sarcomas: A Systematic Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Paediatric soft tissue sarcomas (pSTS) are a rare and heterogeneous group of malignant tumours arising in tissues of mesenchymal origin. The role of natural killer (NK) cells in pSTS remains poorly understood, with evidence fragmented across small preclinical studies and early‐phase clinical trials.
Raya Dean, Lara V. Graham, Christina Putnam, Rosa Gomes Alves Martins, Daniel T. Harding, Tim J. Underwood, Zoë S. Walters, Matthew D. Blunt   +7 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Calculation and modeling of surface high-frequency pipe heat treatment parameters

Весці Нацыянальнай акадэміі навук Беларусі: Серыя фізіка-тэхнічных навук, 2021
This article describes a device developed and manufactured on the basis of the Physical-Technical Institute of the National Academy of Sciences of Belarus, an induction hardening complex, and a range of parts suitable for processing.
I. I. Vegera, A. I. Matalygo, I. A. Sakavysh, P. U. Tsykunou   +3 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Optimization design and operating parameters of induction heat-ing system for hardening

Вестник Самарского государственного технического университета. Серия: Технические науки, 2021
The paper deals with the problem of optimizing the design and operating parameters of an induction heating system for surface hardening of a steel stepped shaft.
Aleksey V. Pavlushin
doaj   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Evaluating the efficiency of hardening treatment of cylindrical parts made of structural steels

Вестник Самарского университета: Аэрокосмическая техника, технологии и машиностроение, 2018
The investigated objects are solid and hollow notched cylindrical specimens made of structural steels surface-hardened with the use of two techniques: hydraulic shot blasting and air shot blasting.
V. P. Sazanov, V. F. Pavlov, O. Yu. Semyonova, A. A. Prokhorov   +3 more
doaj   +1 more source

Problem-oriented model of the technological process of surface induction hardening

Вестник Самарского государственного технического университета. Серия: Технические науки, 2022
The paper presents a nonlinear two-dimensional numerical model of the temperature and thermal stress fields within a steel billet of complex geometric shape in the surface induction hardening process.
Aleksey V. Pavlushin
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Influence of electrolytic-plasma hardening modes on structure and hardness of 0.34Cr-1Ni-Mo-Fe steel

Eurasian Journal of Physics and Functional Materials, 2021
The article presents the results of studying the process of electrolytic-plasma hardening of 0.34Cr-1NiMo- Fe steel by surface hardening, as well as the results of the current-voltage characteristics of the cathodic electrolytic-plasma process depending ...
B. K. Rakhadilov, Z. A. Satbayeva, R. S. Kozhanova, D. R. Baizhan, M. K. Rakhadilov, G. B. Botabayeva   +5 more
doaj   +1 more source