Results 31 to 40 of about 4,786,440 (266)
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
The Planetary Science JournalLaser-induced breakdown spectroscopy (LIBS) is an analytical technique enabling in situ chemical analysis of planetary surfaces. Its use on the Mars Science Laboratory and Mars 2020 missions has demonstrated the potential for quantifying water in ...
Frédéric Diotte +3 more
doaj +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
The Astrophysical Journal Supplement SeriesTrans-Neptunian objects (TNOs) exhibit a color diversity containing a wealth of clues for understanding complex compositions and the formation history of our solar system.
Chaojiang Zhang +4 more
doaj +1 more source
Report of the Study Group on Future Requirements for Fisheries Assessment Data and Software [ICES Headquarters, 21 October, 1997] [PDF]
, 1998 Contributor: Knut SunnanåIntroduction: Since the development of IFAP many new analytical methods have been developed which are in common usage by assessment working groups. It has proved time consuming or impossible to incorporate these tools into IFAP
ICES
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Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
mBio, 2018 The discovery of integrative conjugative elements (ICEs) in wall-less mycoplasmas and the demonstration of their role in massive gene flows within and across species have shed new light on the evolution of these minimal bacteria. Of these, the ICE of the
Eric Baranowski +8 more
doaj +1 more source
Report of the Study Group on Management of Integrated (SGMID) [PDF]
, 2006 The ICES Study Group on Management of Integrated Data met for the third and last time. The group convened at the ICES secretariat at the same time as the annual meeting of the Working Group on Marine Data Management (WGMDM), and half a day was devoted to
ICES
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Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Lunar North Polar Cold Traps Based on Diurnally and Seasonally Varying Temperatures
The Planetary Science JournalLunar cold traps are defined by extremely low sublimation rates, such that water ice could have accumulated in them. Here time-averaged sublimation rates are calculated for the north polar region of the Moon based on over 14 years of Diviner surface ...
Norbert Schörghofer +2 more
doaj +1 more source