Results 51 to 60 of about 4,514,829 (351)
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
The Astrophysical JournalVapor pressure is a relevant quantity that is necessary in order to improve the study of the atmosphere dynamics that take place within astrophysical scenarios.
C. Millán +4 more
doaj +1 more source
Joint ICES/IOC Working Group on Harmful Algal Bloom Dynamics (WGHABD; outputs from 2020 meeting).
, 2021 The ICES/ IOC Working Group on Harmful Algal Bloom Dynamics (WGHABD), co-sponsored by the International Oceanographic Commission (IOC) of UNESCO Intergovernmental Panel for Harmful Algal Blooms (IPHAB), looks at the dynamics of harmful algal blooms (HABs)
ICES
core +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
History of Ceres’s Cold Traps Based on Refined Shape Models
The Planetary Science JournalPermanently shadowed regions (PSRs) in the north polar region of Ceres have been previously mapped by the Dawn spacecraft. Putative ice deposits are found in some of these PSRs, whereas most PSRs host no bright deposits, which is thought to be due to ...
Norbert Schorghofer +3 more
doaj +1 more source
Investigating the Stability and Distribution of Surface Ice in Mercury’s Northernmost Craters
The Planetary Science Journal, 2023 Observations made by Earth-based radar telescopes and the MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) spacecraft provided compelling evidence for water ice in Mercury's polar craters.
Allison K. Glantzberg +10 more
doaj +1 more source
NAFO/ICES Pandalus Assessment Group Meeting [20–27 October 2010 ICES Headquarters, Copenhagen Denmark] [PDF]
, 2010 Contributors: Carsten Hvingel (Co-chair), Guldborg Søvik and Trond ...
ICES
core
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source