Results 51 to 60 of about 6,580 (316)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

History of Ceres’s Cold Traps Based on Refined Shape Models

The Planetary Science Journal
Permanently shadowed regions (PSRs) in the north polar region of Ceres have been previously mapped by the Dawn spacecraft. Putative ice deposits are found in some of these PSRs, whereas most PSRs host no bright deposits, which is thought to be due to ...
Norbert Schorghofer, Robert Gaskell, Erwan Mazarico, John Weirich   +3 more
doaj   +1 more source

Inderwater noise characteristics of TINRO-Center’s reseach vessels

Известия ТИНРО, 2014
Underwater noise radiated by two medium-tonnage research vessels of Pacific Fish. Res. Center (TINRO) belonged to the same project «Atlantic-833» (RV TINRO and Professor Kaganovsky) is measured by a calibrated hydrophone system.
Michail Yu. Kuznetsov, Vasiliy I. Shevtsov, Vladimir I. Poljanichko   +2 more
doaj   +1 more source

Sieved mass and shape data from simulated fluvial transport of icy clasts in the Titan Tumbler

Data in Brief, 2022
Data in this article are related to the research article “Rapid rounding of icy clasts during simulated fluvial transport in the Titan Tumbler”. Whereas that research focused on low-temperature ice abrasion in the context of Saturn's moon Titan, the full
Anthony D. Maue, Joseph S. Levy, Devon M. Burr, Patrick R. Matulka, Erica Nathan   +4 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Water and carbon dioxide ices-rich areas on comet 67P/CG nucleus surface [PDF]

, 2017
So far, only two ice species have been identified by Rosetta/VIRTIS-M [1] on the surface of 67P/Churyumov-Gerasimenko during the pre-perihelion time: crystalline water and carbon dioxide ice.
Bockelée-Morvan, Dominique, Tosi, F., Capria, Maria Teresa, Migliorini, A., MIGLIORINI, Alessandra, Tosi, Federico, Erard, Stéphane, Erard, S., Leyrat, Cédric, CAPACCIONI, FABRIZIO, Capria, M. T., Arnold, G., Ciarniello, M., Raponi, A., Kappel, David, Leyrat, C., Desanctis, M.C., McCord, Thomas B., Capaccioni, F., Bockelee-Morvan, D., Barucci, Maria Antonella, McCord, T. B., Arnold, Gabriele, Filacchione, G., FILACCHIONE, GIANRICO, Kappel, D., CIARNIELLO, Mauro, RAPONI, Andrea, Barucci, M. A., DE SANCTIS, MARIA CRISTINA   +29 more
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Experimental investigation of O2 diffusion and entrapment in interstellar amorphous solid water

Astronomy & Astrophysics
Context. Interstellar ices are mainly composed of amorphous solid water (ASW) containing small amounts of hypervolatiles, such as O2, whose diffusion-limited reactions play a key role in space chemistry.
Coulaud L., Santos J. C., Chuang K.-J.
doaj   +1 more source

Ice on the Moon's Surface [PDF]

Nature, 1886
IN May 1884 Mr. Peal, of Sibsagar, in Assam, who has studied the moon's surface with great attention, sent me a paper in which he maintained views closely resembling those of Capt. Ericsson (NATURE, p. 248) on the glacial origin of the lunar craters.
openaire   +2 more sources