Results 71 to 80 of about 4,514,829 (351)

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

open access: yesFEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta   +7 more
wiley   +1 more source

Report of the Working Group on Ecosystem Effects of Fishing Activities (WGECO) [PDF]

open access: yes, 2006
It has been several years since ICES has completed a comprehensive review of the effects of fishing on the North Sea ecosystem, and this year our ToR (Section 3) has allowed us to revisit this important topic.
ICES
core  

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

open access: yesFEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose   +9 more
wiley   +1 more source

Joint ICES/NAFO Working Group on Deep-water Ecology (WGDEC)

open access: yes
The Working Group on Deep-water Ecology (WGDEC) deals with the biology and conservation of deep-sea habitats in the North Atlantic. Working Group experts collate new information on the distribution of Vulnerable Marine Ecosystems (VMEs) and fishing ...
ICES
core   +2 more sources

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

open access: yesFEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard   +12 more
wiley   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

open access: yesFEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks   +4 more
wiley   +1 more source

ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

open access: yesFEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley   +5 more
wiley   +1 more source

Pwyll and Manannán Craters as a Laboratory for Constraining Irradiation Timescales on Europa

open access: yesThe Planetary Science Journal
We examine high-spatial-resolution Galileo/Near-Infrared Mapping Spectrometer observations of the young (∼1 My–∼20 My) impact features, Pwyll and Manannán craters, on Europa’s trailing hemisphere in an effort to constrain irradiation timescales.
M. Ryleigh Davis, Michael E. Brown
doaj   +1 more source

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