Results 61 to 70 of about 6,580 (316)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Surface activity of Atlantic salmon (Salmo salar) in net pens [PDF]

, 1988
An important feature of the behaviour of salmon is the leaping and rolling activity. These surface activities were studied in fish in net pens in relation to environmental factors and operational procedures. Data were collected manually and automatically
Fernö, Anders, Furevik, Dag M., Bjordal, Åsmund, Huse, Ingvar   +3 more
core  

Optical Spectroscopy of the Uranian Moons from Equinox to Northern Summer

The Planetary Science Journal
We present an analysis of ground-based visible and near-infrared wavelength (VIS, ∼0.4–0.9 μ m) reflectance spectra of the four largest Uranian satellites, utilizing observations with multiple telescopes, collected near Uranian equinox and in northern ...
Riley A. DeColibus, Richard J. Cartwright, William M. Grundy, Bonnie J. Buratti, Michael D. Hicks, Ishan Mishra   +5 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

The atlantic inflow to the North Sea and the Skagerrak indicated by surface observations [PDF]

, 1978
By means of surface observations of temperature and salinity along shipping routes across the North Sea it is shown that the Atlantic inflow along the western and southern edge of the Norwegian Channel seems to reach the surface during winter. This gives
Sætre, Roald
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Working Group on Acoustic and Egg Surveys for small pelagic fish in Northeast Atlantic (WGACEGG; outputs from 2023 meeting).

WGACEGG coordinates and provides quality control for acoustic and daily egg production (DEPM) surveys of several pelagic stocks in ICES areas 6-9. During the 2023 meeting results from four DEPM surveys and nine acoustic surveys were pre-sented and ...
ICES
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Jens Eggvin – A Norwegian pioneer in operational oceanography [PDF]

, 2002
Jens Eggvin (1899-1989) was employed at the Institute of Marine Research (IMR) in Bergen as head of its physical oceanographic activities in 1933. He followed a Norwegian tradition in relating the physical conditions of the ocean with fisheries.
Sætre, Roald, Blindheim, Johan
core  

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source