Results 31 to 40 of about 562,540 (263)

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Determination of the Depth of Cut via Surface Integrity

open access: yesApplied Sciences, 2023
The present paper continues the authors’ research in machining process optimization, including the direction of machining parameters optimization. The paper develops an innovative method, via surface integrity, for determining the technological route and
Cristina Gavrus   +2 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

open access: yesFEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas   +3 more
wiley   +1 more source

Influence of Milling Tool and Prosthetic Materials on Roughness of the Dental CAD CAM Prostheses in End Milling Mode

open access: yesApplied Sciences, 2020
Dental prostheses are machined by computer-aided design and manufacturing (CAD/CAM) tools. The integrity of the surface obtained, which must be suitable to meet expected clinical requirements is influenced by the milling parameters programmed.
Nicolas Lebon   +2 more
doaj   +1 more source

Investigation of the effects of machining parameters on surface integrity in micromachining

open access: yesOpen Chemistry, 2022
In this study, the effect of cutting conditions on surface integrity was investigated in micromilling of magnesium alloy (AZ91). Microtool diameter, cutting speed, feed rate, and depth of cut parameters are used.
Etyemez Ayhan, Aydin Umut
doaj   +1 more source

Research on the Tooth Surface Integrity of Non-Circular Gear WEDM Based on HPSO Optimization SVR

open access: yesApplied Sciences, 2022
Non-circular gears have the characteristics of gear ratio accuracy, good dynamic performance, and wide application prospects but are difficult to manufacture.
Jiali Zhao   +5 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

open access: yesFEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga   +3 more
wiley   +1 more source

Multi-Response Optimization of Electrical Discharge Machining Using the Desirability Function

open access: yesMicromachines, 2019
Electrical discharge machining (EDM) is a modern technology that is widely used in the production of difficult to cut conductive materials. The basic problem of EDM is the stochastic nature of electrical discharges.
Rafał Świercz   +2 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Metals Machining—Recent Advances in Experimental and Modeling of the Cutting Process

open access: yesMetals, 2018
Metal machining involves severe loading in the cutting zone. [...]
Badis Haddag
doaj   +1 more source

Home - About - Disclaimer - Privacy