Results 101 to 110 of about 2,011,030 (309)

Qualitative Enhancement of the Tooth–Filling Interface Using Cold Atmospheric Plasma

Dentistry Journal
Objective: To evaluate the effects of cold atmospheric plasma (CAP) on adhesive bonding in Class II composite restorations in vitro. Methods: Forty-eight standardized Class II cavities were assigned to six groups (n = 8), varying in phosphoric acid ...
Madline Priska Gund, Jusef Naim, Muhammad al Muhammad, Antje Lehmann, Axel Schindler, Matthias Hannig, Stefan Rupf   +6 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Deposition processes of superhard diamond-like carbon films co-adjusted by ion energy and ion flux in arc discharges

Journal of Materials Research and Technology
As a kind of protective material, Diamond-Like Carbon (DLC) film can effectively improve the mechanical and tribological properties of the substrate surface.
Minglei Wang, Lin Zhang, Guoqiang Lin
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Experimental study of the correlation length of critical-current fluctuations in the presence of surface disorder: Probing vortex long-range interactions

, 2006
We report on critical currents and voltage noise measurements in Niobium strips in the superconducting state, in the presence of a bulk vortex lattice ($B < B_{C2}$) and in the surface superconducting state ($B_{c2}< B < B_{C3}$).
A. Pautrat, C. Goupil, Ch. Simon, H. Ulmaier, I. O. Kulik, J. Scola, W. DeSorbo, Y. Paltiel   +7 more
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Modification Design and Experimental Verification of Spiral Bevel Gear Tooth Surface Based on Quantitative Mismatch

Jixie chuandong, 2023
A method for designing tooth surface of spiral bevel gears based on quantitative mismatch modification is proposed in this study. Firstly, the mathematical relationship between modification quantity, modification coefficient and structural parameters of ...
Geng Longlong, Nie Shaowu, Jiang Chuang
doaj  

Effects of Multi-Surface Modification on Curie temperature of ferroelectric films

, 1999
Within the framework of mean field theory, we study the effects of multi-surface modification on Curie temperature of ferroelectric films using the transverse Ising model.
Anliker M, Bell A J, Binder K, Binder K, Blinc R, Cottam M G, de Gennes P D, Elliott R J, Elliott R J, Guo-Zhen Yang, Jaccard A, Landau L D, McCauley D, Shao-Hua Pan, Stinchcombe R B, Swartz S L, Sy H K, Wang C L, Wang X Z, Xiao-Guang Wang, Yariv A, Zhong W L   +21 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source