Results 81 to 90 of about 2,011,030 (309)

Modifying monolayer behaviour by incorporating subphase additives and improving Langmuir–Blodgett thin film deposition on optical fibres [PDF]

, 2014
Experiments showing the possibility of modifying the behaviour of calix[4]resorcinarene monolayers at the air–water interface and optimising the deposition of multilayer coatings onto optical fibres are presented.
Collins, Mike, Davis, Frank, Higson, Seamus P. J., James, Stephen W., Partridge, Matthew, Tatam, Ralph P., Wong, Rebecca   +6 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Entanglement entropy of Wilson surfaces from bubbling geometries in M-theory [PDF]

, 2015
We consider solutions of eleven-dimensional supergravity constructed in [1,2] that are half-BPS, locally asymptotic to $AdS_7\times S^4$ and are the holographic dual of heavy Wilson surfaces in the six-dimensional $(2,0)$ theory.
A Gustavsson, A Kapustin, A Lewkowycz, A Lewkowycz, A Strominger, B Chen, B Chen, C Bachas, Chrysostomos Marasinou, CR Graham, D Bak, D Young, DE Berenstein, E D’Hoker, E D’Hoker, E D’Hoker, E D’Hoker, E D’Hoker, H Casini, H Lin, H Mori, H-C Chang, J Estes, J Gomis, J Gomis, J Gomis, JA Minahan, JM Maldacena, JM Maldacena, K Jensen, K Pilch, K Skenderis, M Günaydin, M Henningson, Michael Gutperle, MR Douglas, O Aharony, O Lunin, O Lunin, OJ Ganor, P Kraus, P Nieuwenhuizen van, R Corrado, RG Leigh, S Haro de, S Ryu, S Ryu, S Yamaguchi, S-J Rey, SA Gentle, Simon A. Gentle, T Nishioka, T Okuda, V Pestun   +53 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Uncovering predictors of myopia in youth: a secondary data analysis using a machine learning approach

Frontiers in Medicine
IntroductionMyopia is a multifactorial condition driven by an interplay of genetic predisposition and environmental triggers. This study aims to harmonize and analyze risk predictors from two distinct datasetsone historical and clinical, the other ...
Jiajia Liao, Zhijie Chen, Wanqing Jin
doaj   +1 more source

The influence of the surface morphology of dental implants on bone integration

Fogorvosi Szemle, 2019
Surface morphology of dental implants is one of the Bränemark osseointegration conditions formulated in the eighties. In the past couple of decades – as in many other areas within oral implantology – significant changes have taken place.
Ferenc Koppány
doaj   +1 more source