Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structural and microstructural study of gamma ray-irradiated co-doped barium titanate (Ba0.88Ca0.12Ti0.975Sn0.025O3) [PDF]
Barium calcium stannate titanate (Ba0.88Ca0.12Ti0.975Sn0.025O3) ceramics, synthesized by solid state reaction method and sintered at 1100 °C/3 h, were exposed to gamma radiation dose of up to 1 kGy using a Cs-137 irradiation source at a dose rate of 100 ...
Umaru Ahmadu +4 more
doaj +1 more source
Discerning protein pools by selective staining with self‐labeling tags
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Seismic hazard analysis and risk classification for major dams in Thailand: a nationwide study
Background Seismic hazards pose increasing challenges to the safety of large dams in Thailand, particularly those located near active fault systems.
Santi Pailoplee +4 more
doaj +1 more source
Influence of Rock Surface Morphology on Runoff and Sediment in Karst Slope of Southwest China
[Objective] The aim of the study is to explore the influence of exposed rock surface morphology on the runoff and sediment yield of karst slope, and then to enhance the understanding of rainfall erosion pattern on karst slopes. [Methods] The artificially
AO Liman +5 more
doaj
The femtosecond‐pulsed laser processed black silicon (fs‐bSi) features high absorptance in a wide spectral range but suffers from high amount of laser induced damage as compared with bSi fabricated by other methods.
Xiaolong Liu +5 more
doaj +1 more source
Morphology of graphene on SiC(0001¯) surfaces [PDF]
Graphene is formed on SiC(0001¯) surfaces (the so-called C-face of the crystal) by annealing in vacuum, with the resulting films characterized by atomic force microscopy, Auger electron spectroscopy, scanning Auger microscopy, and Raman spectroscopy. Morphology of these films is compared with the graphene films grown on SiC(0001) surfaces (the Si-face).
Luxmi +7 more
openaire +2 more sources
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Inner ear morphology in the Atlantic molly Poecilia mexicana - first detailed microanatomical study of the inner ear of a cyprinodontiform species [PDF]
Background: Fishes show an amazing diversity in hearing abilities, inner ear structures, and otolith morphology. Inner ear morphology, however, has not yet been investigated in detail in any member of the diverse order Cyprinodontiformes.
Heß, Martin +8 more
core +2 more sources
Liver organoids: modelling complexity in homeostasis and disease
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source

