Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Does people oriented urbanization catch up with land and population urbanization
npj Urban SustainabilityRecently, China has undergone rapid urbanization in terms of population and urban land growth. However, there are notable lags in the people-oriented dimensions of urbanization, including urban social services, environmental services, and socioeconomic ...
Tianci Gu +11 more
doaj +1 more source
Isolation of pseudocapacitive surface processes at monolayer MXene flakes reveals delocalized charging mechanism. [PDF]
Nat Commun, 2023 Brunet Cabré M +8 more
europepmc +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Surface Processes Control the Fate of Reactive Oxidants Generated by Electrochemical Activation of Hydrogen Peroxide on Stainless-Steel Electrodes. [PDF]
Environ Sci Technol, 2023 Duan Y, Jiang W, Sedlak DL.
europepmc +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Influence of monolayer contamination on electric-field-noise heating in ion traps
, 2012 Electric field noise is a hinderance to the assembly of large scale quantum computers based on entangled trapped ions. Apart from ubiquitous technical noise sources, experimental studies of trapped ion heating have revealed additional limiting ...
Kim, E. +4 more
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Joint UK Land Environment Simulator (JULES) Version 2.2 User Manual [PDF]
, 2010 The Joint UK Land Environment Simulator (JULES) is a computer model that simulates many soil and vegetation processes. This document describes how to run version 2.2 of JULES.
Clark, Douglas +3 more
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