Results 101 to 110 of about 1,411,347 (265)

Multiyear in-situ L-band microwave radiometry of land surface processes on the Tibetan Plateau. [PDF]

Sci Data, 2020
Su Z, Wen J, Zeng Y, Zhao H, Lv S, van der Velde R, Zheng D, Wang X, Wang Z, Schwank M, Kerr Y, Yueh S, Colliander A, Qian H, Drusch M, Mecklenburg S.   +15 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Kinetic Modeling of Grain Boundary Diffusion: The Influence of Grain Size and Surface Processes. [PDF]

Materials (Basel), 2020
Jaseliunaite J, Galdikas A.
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Geospatial green ammonia co-firing in China’s coal power fleets to avoid CO2 emissions lock-in

Nature Communications
China’s 600 gigawatts (GW) of post-2010 coal power capacity locks in over 2 gigatons (Gt) of annual CO₂ emissions. Green ammonia co-firing offers a viable decarbonization pathway, yet spatial mismatch between ammonia production hubs and coal power plants
Huihuang Wu, Xiurong Hu, Xian Wang, Yuhan Zhou, Junfeng Liu, Yang Ren, Boyang Wu, Wendong Ge, Ying Liu, Shu Tao   +9 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

The Inverted U‐Shaped Relationship Between Socio‐Economic Status and Infections During the COVID‐19 Pandemic

GeoHealth
Although the World Health Organization has declared that the COVID‐19 pandemic no longer qualifies as a global public health emergency, it still needs to explore the response of society to the COVID‐19 pandemic.
Yelin Sun, Weihang Liu, Gangfeng Zhang, Peijun Shi   +3 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Process, Causes, and Loss Assessment of the Extreme Wind-Dust Compound Disaster in China in April 2025

International Journal of Disaster Risk Science
From 10 to 15 April 2025, China experienced a rare persistent extreme wind-dust compound disaster that swept from north to south. Based on observational data, historical disaster records, and situations of various exposed elements, this study analyzed ...
Gangfeng Zhang, Yiwen Wang, Lianyou Liu, Yaoyao Ma, Ziqi Lin, Wenxuan Li, Tong Zhang, Siqi Liu, Xiaoxiao Zhang, Shuo Wang, Zhe Liu, Jinpeng Hu, Peijun Shi   +12 more
doaj   +1 more source