Results 121 to 130 of about 9,664,885 (256)

Declines in anthropogenic mercury emissions in the Global North and China offset by the Global South

Nature Communications
Human activities have emitted substantial mercury into the atmosphere, significantly impacting ecosystems and human health worldwide. Currently, consistent methodologies to evaluate long-term mercury emissions across countries and industries are scant ...
Xinran Qiu, Maodian Liu, Yuanzheng Zhang, Qianru Zhang, Huiming Lin, Xingrui Cai, Jin Li, Rong Dai, Shuxiu Zheng, Jinghang Wang, Yaqi Zhu, Huizhong Shen, Guofeng Shen, Xuejun Wang, Shu Tao   +14 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Contribution of intercepted subsurface flow to road runoff and sediment transport in a logging-disturbed tropical catchment

, 2008
10.1002/esp.1606Earth Surface Processes and Landforms3381174 ...
Sidle, R.C., Noguchi, S., Noguchi, S, Sidle, Roy C, Negishi, J.N., Ziegler, A.D., Ziegler, A D, Rahim, N A, Negishi, J N, Rahim, N.A.   +9 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Geospatial green ammonia co-firing in China’s coal power fleets to avoid CO2 emissions lock-in

Nature Communications
China’s 600 gigawatts (GW) of post-2010 coal power capacity locks in over 2 gigatons (Gt) of annual CO₂ emissions. Green ammonia co-firing offers a viable decarbonization pathway, yet spatial mismatch between ammonia production hubs and coal power plants
Huihuang Wu, Xiurong Hu, Xian Wang, Yuhan Zhou, Junfeng Liu, Yang Ren, Boyang Wu, Wendong Ge, Ying Liu, Shu Tao   +9 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Process, Causes, and Loss Assessment of the Extreme Wind-Dust Compound Disaster in China in April 2025

International Journal of Disaster Risk Science
From 10 to 15 April 2025, China experienced a rare persistent extreme wind-dust compound disaster that swept from north to south. Based on observational data, historical disaster records, and situations of various exposed elements, this study analyzed ...
Gangfeng Zhang, Yiwen Wang, Lianyou Liu, Yaoyao Ma, Ziqi Lin, Wenxuan Li, Tong Zhang, Siqi Liu, Xiaoxiao Zhang, Shuo Wang, Zhe Liu, Jinpeng Hu, Peijun Shi   +12 more
doaj   +1 more source