Results 121 to 130 of about 27,708,048 (352)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Does people oriented urbanization catch up with land and population urbanization

npj Urban Sustainability
Recently, China has undergone rapid urbanization in terms of population and urban land growth. However, there are notable lags in the people-oriented dimensions of urbanization, including urban social services, environmental services, and socioeconomic ...
Tianci Gu, Qingxu Huang, Mingxing Chen, Chunyang He, Guoliang Zhu, Yiming Hou, Yihan Zhou, Kaihong Yue, Ming Zhang, Shiyu Zhang, Yizhou Xie, Jiasheng Wang   +11 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Effects of anthropogenic groundwater exploitation on land surface processes: A case study of the Haihe River Basin, northern China

, 2014
In this study, we incorporated a groundwater exploitation scheme into the land surface model CLM3.5 to investigate the effects of the anthropogenic exploitation of groundwater on land surface processes in a river basin.
Jing Zou, Zhenghui Xie, Che-sheng Zhan, Peihua Qin, Qin Sun, Binghao Jia, J. Xia   +6 more
semanticscholar   +1 more source

NDVI-Based Analysis on the Influence of Climate Change and Human Activities on Vegetation Restoration in the Shaanxi-Gansu-Ningxia Region, Central China

Remote Sensing, 2015
In recent decades, climate change has affected vegetation growth in terrestrial ecosystems. We investigated spatial and temporal patterns of vegetation cover on the Loess Plateau’s Shaanxi-Gansu-Ningxia region in central China using MODIS-NDVI data for ...
Shuangshuang Li, Saini Yang, Xianfeng Liu, Yanxu Liu, Mimi Shi   +4 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Experimental study on photodegradation and leaching of typical pesticides in greenhouse soil from Shouguang, Shandong Province, East China

Ecological Processes
Background Pesticide use contributes to national food security. The dissipation pathways and degradation mechanisms of pesticides have been widely studied and pesticide residues have remained a focus of public concern.
Li-Ting Hua, Rui-Lin Wu, Cun-Lu Li, Chao-Nan Wang, Yi-Long Li, Fu-Liu Xu   +5 more
doaj   +1 more source

Surface Processes Control the Fate of Reactive Oxidants Generated by Electrochemical Activation of Hydrogen Peroxide on Stainless-Steel Electrodes. [PDF]

Environ Sci Technol, 2023
Duan Y, Jiang W, Sedlak DL.
europepmc   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Investigations on the energy influx at plasma surface processes

, 2000
A summary is given of different elementary processes influencing the thermal balance and energetic conditions of substrate surfaces during plasma processing.
Deutsch, H., Hippler, R., Rohde, D., Stoffels - Adamowicz, E., Kersten, H., Berndt, J., Stoffels, W.W., Kroesen, G.M.W.   +7 more
core