Results 131 to 140 of about 27,708,048 (352)

Coupled influence of tectonics, climate, and surface processes on landscape evolution in southwestern North America. [PDF]

Nat Commun, 2022
Bahadori A, Holt WE, Feng R, Austermann J, Loughney KM, Salles T, Moresi L, Beucher R, Lu N, Flesch LM, Calvelage CM, Rasbury ET, Davis DM, Potochnik AR, Ward WB, Hatton K, Haq SSB, Smiley TM, Wooton KM, Badgley C.   +19 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

The zoogeomorphology of case‐building caddisfly: Quantifying sediment use

, 2019
Caddisfly (Trichoptera) larvae are an abundant and widespread aquatic insect group characterised by the construction of silk structures, including nets and cases.
Stephen Rice (1255812), Richard Mason (3187401), Johnson, Matthew F., Paul J. Wood, Matthew F. Johnson, Mason, Richard J., Paul Wood (1255125), Rice, Stephen P., Wood, Paul J., Matthew F. Johnson (7190480), Richard J. Mason, Stephen P. Rice, Mason, Richard J.,   +12 more
core   +1 more source

The Contribution of Surface and Submesoscale Processes to Turbulence in the Open Ocean Surface Boundary Layer

Journal of Advances in Modeling Earth Systems, 2019
The ocean surface boundary layer is a critical interface across which momentum, heat, and trace gases are exchanged between the oceans and atmosphere. Surface processes (winds, waves, and buoyancy forcing) are known to contribute significantly to fluxes ...
Christian E. Buckingham, N. Lucas, S. Belcher, T. Rippeth, A. Grant, J. Le Sommer, A. Ajayi, A. N. Naveira Garabato   +7 more
semanticscholar   +1 more source

Surface Condition Evolution and Fatigue Evaluation after Different Surface Processes for TiAl₄₇Cr₂Nb₂ Alloy. [PDF]

Materials (Basel), 2022
Yu W, Yin Y, Zhou J, Xu Q, Feng X, Nan H, Zuo J, Wang X, Ding X.   +8 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Surface location error for helical mills

, 2006
Stability and surface location error are investigated numerically for milling operations with a helical tool. A detailed mechanical model is derived that includes both surface regeneration and the helical teeth of the tool.
Bachrathy, D, Homer, ME, Insperger, T, Stepan, G   +3 more
core  

Modelling the Interfacial Flow of Two Immiscible Liquids in Mixing Processes

, 2005
This paper presents an interface tracking method for modelling the flow of immiscible metallic liquids in mixing processes. The methodology can provide an insight into mixing processes for studying the fundamental morphology development mechanisms for ...
Tang, H, L.C. Wrobel, H. Tang, Wrobel, L C   +3 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source