Results 111 to 120 of about 27,708,048 (352)

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Mechanisms for surface potential decay on fluorinated epoxy in high voltage DC applications [PDF]

, 2014
Epoxy resin has been extensively used for decades as an insulation material in high voltage transmission systems. However, this insulation material does suffer from bulk and surface charging when used as insulating spacer, mainly in high voltage DC ...
Z. An, Mohamad, A., Y. Zhang, An, Z., A. Mohamad, Chen, G., G. Chen, Zhang, Y.   +7 more
core   +1 more source

Comparison of Maraging Steel Surface Integrity in Hybrid and Conventional Micro-ECDM Processes

, 2022
Maraging steel is one of the exotic materials showing the potential for application in the field of the aerospace industry. However, machining these materials with high surface quality and material removal rate is problematic.
Sergej Hloch, Das, Alok Kumar, Mandal, Niladri, Hloch, Sergej, Alok Kumar Das, Niladri Mandal   +5 more
core   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

ALPINE3D: a detailed model of mountain surface processes and its application to snow hydrology

, 2006
Current models of snow cover distribution, soil moisture. surface runoff and river discharge typically have very simple parameterizations of surface processes, such as degree-day factors or single-layer snow cover representation.
Massimiliano Zappa, David Gustafsson, Manfred Stähli, Voelksch, Ingo, Zappa, Massimiliano, Tuan Anh Nguyen, Staehli, Manfred, Michael Lehning, Ingo Völksch, Gustafsson, David,, Lehning, Michael, Nguyen, Tuan Anh   +11 more
core   +1 more source

Surface-analytical Studies on Environmental and Geochemical Surface Processes

Analytical Sciences, 2003
The surface chemical compositions of solid samples from environmental and geological sources can differ from the bulk or average compositions, because of changes caused by adsorption, dissolution, oxidation, etc. Accordingly, analytical information on surface layers is important for a better understanding of the environmental chemistry involving solid ...
SEYAMA, Haruhiko, SOMA, Mitsuyuki
openaire   +3 more sources

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Spectral Domain Low- Coherence Interferometry for On-line Surface Inspection [PDF]

, 2013
We present an on-line surface measurement technique based on spectral domain low-coherence interferometry (SD-LCI), which can obtain a one dimensional surface profile with just one shot.
Gao, F., Jiang, X., Jiang, Xiangqian, Jiang, Xiang, Gao, Feng, Tang, Dawei   +5 more
core   +1 more source

Levels, Distribution, and Health Risks of Polycyclic Aromatic Hydrocarbons in Four Freshwater Edible Fish Species from the Beijing Market

The Scientific World Journal, 2012
We first estimated the content of polycyclic aromatic hydrocarbons (PAHs) in the brain, liver, bladder, roe, and muscle of four species of edible freshwater fish from the Beijing market.
Wen-Jing Wu, Ning Qin, Wei He, Qi-Shuang He, Hui-Ling Ouyang, Fu-Liu Xu   +5 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source