Results 131 to 140 of about 4,224,482 (302)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Multiyear in-situ L-band microwave radiometry of land surface processes on the Tibetan Plateau. [PDF]

Sci Data, 2020
Su Z, Wen J, Zeng Y, Zhao H, Lv S, van der Velde R, Zheng D, Wang X, Wang Z, Schwank M, Kerr Y, Yueh S, Colliander A, Qian H, Drusch M, Mecklenburg S.   +15 more
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Kinetic Modeling of Grain Boundary Diffusion: The Influence of Grain Size and Surface Processes. [PDF]

Materials (Basel), 2020
Jaseliunaite J, Galdikas A.
europepmc   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Process, Causes, and Loss Assessment of the Extreme Wind-Dust Compound Disaster in China in April 2025

International Journal of Disaster Risk Science
From 10 to 15 April 2025, China experienced a rare persistent extreme wind-dust compound disaster that swept from north to south. Based on observational data, historical disaster records, and situations of various exposed elements, this study analyzed ...
Gangfeng Zhang, Yiwen Wang, Lianyou Liu, Yaoyao Ma, Ziqi Lin, Wenxuan Li, Tong Zhang, Siqi Liu, Xiaoxiao Zhang, Shuo Wang, Zhe Liu, Jinpeng Hu, Peijun Shi   +12 more
doaj   +1 more source

Land-surface processes and summer-cloud-precipitation characteristics in the Tibetan Plateau and their effects on downstream weather: a review and perspective. [PDF]

Natl Sci Rev, 2020
Fu Y, Ma Y, Zhong L, Yang Y, Guo X, Wang C, Xu X, Yang K, Xu X, Liu L, Fan G, Li Y, Wang D.   +12 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Determination and impact of surface radiative processes for TOGA COARE [PDF]

Experiments using atmospheric general circulation models have shown that the atmospheric circulation is very sensitive to small changes in sea surface temperature in the tropical western Pacific Ocean warm pool region. The mutual sensitivity of the ocean
Ackerman, Thomas, Curry, Judith A., Rossow, William B., Webster, Peter J.   +3 more
core   +1 more source