Results 101 to 110 of about 1,431,352 (314)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Biological and water quality study of Big Darby Creek and selected tributaries, 2001/2002 : Logan, Champaign, Union, Madison, Franklin and Pickaway counties, Ohio.

, 2004
Title from home page (viewed on Aug. 23, 2006).; "Prepared by State of Ohio Environmental Protection Agency, Division of Surface Water ..."--PDF t.p.; "June 28, 2004."; Harvested from the web on 8/23 ...
Ohio EPA. Division of Surface Water.
core  

Surface Quality Improvement of Atmospheric Pressure Plasma Polishing (APPP) in Machining of Silicon Ultra-Smooth Surfaces

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2012
To produce ultra-smooth optical surfaces on hard brittle materials and functional crystal materials without surface damage, atmospheric pressure plasma polishing (APPP) is developed.
Jufan ZHANG, Bing LI, Bo WANG, Shen DONG
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Integrated water quality monitoring and assessment report, Ohio 2002

, 2002
Title from web page.; "Prepared to fulfill the requirements of Sections 305(b) and 303(d) of the Clean water Act."; "October 1, 2002, final for U.S.
Ohio EPA.Division of Surface Water.
core  

Tool wear monitoring and hole surface quality during CFRP drilling [PDF]

, 2014
The present investigation focuses on the evaluation of tool wear and surface integrity in the context of CFRP cutting. Series of drilling experiments were performed on CFRP plates using cemented carbide solid drills with the aim to investigate ...
RAMIREZ, Christophe, M'SAOUBI, Rachid, POULACHON, Gerard, ROSSI, FREDERIC   +3 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Machining Unidirectional Composites using Single-Point Tools: Analysis of Cutting Forces, Chip Formation and Surface Integrity

, 2015
The need for high quality machining of composite materials is rising due to the increased utilisation of these materials across several applications. This paper presents experimental findings of orthogonal cutting of unidirectional glass fibre reinforced
Kahwash, Fadi, Maheri, A., Shyha, Islam, Kahwash, F., Shyha, I., Maheri, Alireza   +5 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source