E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Water-quality assessment of the Kentucky River Basin, Kentucky; analysis of available surface-water-quality data through 1986, with a section on biological indicators of water quality [PDF]
, 1995 J.L. Smoot +4 more
openalex +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Materials Research ExpressUltrasonic vibration cutting technology has made remarkable progress in the application of hard and brittle materials, but there are still some challenges in aerospace silicon carbide fiber toughened silicon carbide ceramic matrix composite (SiCf/SiC ...
Dengzhou Hu +4 more
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Assessment of Surface Water Quality on the Upper Watershed of Huallaga River, in Peru, using Grey Systems and Shannon Entropy [PDF]
, 2020 Alexi Delgado +4 more
openalex +1 more source
Production of a water quality map of Saginaw Bay by computer processing of LANDSAT-2 data [PDF]
Surface truth and LANDSAT measurements collected July 31, 1975, for Saginaw Bay were used to demonstrate a technique for producing a color coded water quality map.
Mckeon, J. B. +2 more
core +1 more source
Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics
FEBS Open Bio, EarlyView.Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini +2 more
wiley +1 more source
Wood planing properties of Australian plantation-grown Eucalypts
Maderas: Ciencia y Tecnología, 2016 Planing properties of seven Australian plantation-grown eucalypts were evaluated to provide recommendations on how these species should be machined and considered for the manufacture of high quality furniture and furnishings. The surface quality produced
Benoit Belleville +2 more
doaj