Results 61 to 70 of about 443,212 (302)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

On the determination of the earthquake slip distribution via linear programming techniques [PDF]

, 2012
The description that one can have of the seismic source is the mani- festation of an imagined model, obviously outlined from Physic Theories and supported by mathematical methods.
Bushenkov, V., Caldeira, B., Smirnov, G.
core  

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Transform fault earthquakes in the North Atlantic: Source mechanisms and depth of faulting [PDF]

, 1988
The centroid depths and source mechanisms of 12 large earthquakes on transform faults of the northern Mid-Atlantic Ridge were determined from an inversion of long-period body waveforms.
Bergman, Eric A., Solomon, Sean C.
core   +2 more sources

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Earthquake-induced fissures and their formation mechanisms in the 2023 MS 6.2 Jishishan Earthquake

Dizhi lixue xuebao
Objective  Seismic fissures, landslides and mudflows are common secondary hazards of earthquakes. Following the occurrence of moderately strong earthquakes, detailed investigations of landslides and mudflows are usually conducted, but earthquake-induced ...
ZHANG Bo, WANG Aiguo, YAO Yunsheng, HE Xiaolong, YAO Saisai, ZHU Junwen, CAI Yimeng   +6 more
doaj   +1 more source

Mechanics of earthquakes [PDF]

, 1994
An earthquake is a sudden rupture process in the Earth’s crust or mantle caused by tectonic stress. To understand the physics of earthquakes it is important to determine the state of stress before, during, and after an earthquake.
Kanamori, Hiroo
core   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Rupture Strength and Irregularity of Fracture Surfaces [PDF]

IOP Conference Series: Materials Science and Engineering, 2017
Textural irregularities of fracture surfaces of cement-based materials seem to be an interesting source of information on some mechanical properties. Besides compressive strength, the flexural strength is strongly correlated with height irregularities (i.e. roughness) of fracture surfaces of hydrated cement pastes.
openaire   +2 more sources