Results 251 to 260 of about 4,830,776 (306)

Chemoproteomic Identification of AKT2 as a Paclitaxel‐Binding Protein via C─C Bond‐Linked Probe PTX‐4 in Paclitaxel‐Resistant Breast Cancer

Advanced Science, EarlyView.
ABSTRACT Breast cancer remains one of the most prevalent malignancies among women, and taxane‐based chemotherapies such as paclitaxel and docetaxel are central to standard treatment regimens. However, drug resistance in breast cancer limits therapeutic efficacy and contributes to recurrence and metastasis.
Kai Wang, Yuqing Yuan, Wei Shen, Xiuxiu Yang, Xiaokang Wu, Haihua Zhou, Yi Hu, Qing Zhu   +7 more
wiley   +1 more source

Field investigation of the bearing behavior of grouted gravel pile composite foundations in Karst Terrain. [PDF]

PLoS One
Zhang L, Yan C, Jiang C.
europepmc   +1 more source

Mitigating Cancer Therapy–Related Cognitive Impairment by Targeted Activation of Undruggable Phosphatase

Advanced Science, EarlyView.
An RVG‑engineered exosomal saRNA delivery system (RVG‑EVs‑saPtpro) effectively targets and activates hippocampal PTPRO, functioning as a “molecular brake” to alleviate cancer therapy‑related cognitive impairment (CTRCI) by enhancing neuronal survival, neurogenesis, and synaptic plasticity.
Zhimeng Yao, Yuhua Meng, Huanyi Li, Yinhui Jiang, Xiaona Lin, Mengyuan Hu, Qing Liu, Xiaofu Qiu, Hongzheng Ren, Yunlong Pan, Bin Pan, Zexiong Guo, Shuyao Zhang, Dianzheng Zhang, Li Yang, Shegan Gao, Weijing Deng, Jianfan Chen, Hao Zhang   +18 more
wiley   +1 more source

Preliminary Field Performance of a Low-Tortuosity Permeable Pavement System Incorporating Bottom Ash Fine Aggregate for Surface-Temperature Regulation and Stormwater Storage. [PDF]

Materials (Basel)
Park CG, Oh RO, Park SH, Park SK, Kim HH, Stein DG, Yeon J.   +6 more
europepmc   +1 more source

Deformation mechanisms of an existing tunnel adjacent to deep basement supported by circular beams in soft clays. [PDF]

Sci Rep
Qi S, Wang B.
europepmc   +1 more source

Dynamic characteristics and adaptability research of high-speed railway roadbed with silt-cement improved aeolian sand. [PDF]

Sci Rep
Li X, Huang C, Ren K, Yang W, Zhu Y, Han D, Pang X.   +6 more
europepmc   +1 more source

Physics-guided monotone stacking for reliable prediction of pile load-settlement curves using SPT-[Formula: see text] profiles and geometry. [PDF]

Sci Rep
Tipu RK, Alkahtani MQ, Paruthi S, Parvez S.   +3 more
europepmc   +1 more source

Agricultural expansion and mining drive forest loss in Ghana despite declining deforestation rates: Evidence from a national-scale assessment. [PDF]

PLoS One
Addo-Fordjour P, Awortwi FE, Obodai CE, Aboagye FB, France CNL, Kusi-Appiah NSB, Oppong D.   +6 more
europepmc   +1 more source

Water alone did not sustain early humans in the desert

Rose J, Dellmour R, Coco E, Garba R, Samawi O, Eren M, Bebber M, Harzhauser M, Kindi MA, Mahrooqi AA.   +9 more
europepmc   +1 more source

Early life trade-offs in corals selected for adult heat tolerance are absent under heat stress

Humanes A, Steeg Evd, Bythell J, Edwards A, Golbuu Y, Lachs L, Martinez H, Guest J.   +7 more
europepmc   +1 more source