Results 41 to 50 of about 4,830,776 (306)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Characteristics of surface settlement and deformation of open cut foundation pit in different areas of Beijing

Shuiwen dizhi gongcheng dizhi, 2021
Based on a large number of measured data of surface settlement of open cut foundation pit engineering in different areas of Beijing in recent years, the typical curve "Four Point Broken Line Method" and its model parameters (slope K and intercept b) for ...
Jianquan ZHANG, Keli ZHANG, Guifang CHENG   +2 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Centrifuge modeling of tunneling-induced ground surface settlement in sand

Underground Space, 2019
Stress changes in the soil induced by tunnel excavation may cause excessive ground settlement. However, high-quality experimental data on ground settlement due to tunnel excavation are limited. In this study, centrifuge tests are conducted to investigate
Hu Lu, Jiangwei Shi, Yu Wang, Rong Wang
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Bayesian Network-Driven Risk Assessment and Reinforcement Strategy for Shield Tunnel Construction Adjacent to Wall–Pile–Anchor-Supported Foundation Pit

Buildings
With the increasing demand for urban rail transit capacity, shield tunneling has become the predominant method for constructing underground metro systems in densely populated cities.
Yuran Lu, Bin Zhu, Hongsheng Qiu
doaj   +1 more source

Shallow tunneling's impact on surface settlements

The Journal of Engineering and Exact Sciences
The research described in this paper deals with the impact of shallow tunneling on surface settlements in urban areas. The study focuses on carrying out a numerical analysis and a parametric geotechnical study to investigate the effects of tunnel excavation on the surface ground, particularly with regard to distortion and potential damage to structures
Mohamed Djenane, Kamel Bezih
openaire   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Research on historical deformation and rock layer water content variation in large open-pit mining areas based on SBAS and MatDEM

Frontiers in Earth Science
In order to study the characteristics of settlement and deformation evolution of large open pit to underground mine quarries in China, and to analyse the changing law of volumetric water content of overburden rock layers at different mining stages. Based
Jiabo Geng, Jiabo Geng, Cunyang Liu, Cunyang Liu, Cunyang Liu, Xiang Lan, Yunmin Wang, Xing Wang, Xiaobing Wang   +8 more
doaj   +1 more source

Sandy aquifer collapse mechanism and accident treatment of the Qingdao metro tunnel

Frontiers in Earth Science, 2023
The tunnel collapse occurred during the construction of the Qingdao Metro Line Ⅰ, resulting in a pit measuring approximately 10 m in diameter and 7 m in depth on the ground surface.
Liwei Zhang, Zaiquan Wang, Weiguo Zhang, Sijia Liu   +3 more
doaj   +1 more source