Results 51 to 60 of about 5,084,579 (305)

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Analysis and research on vertical displacement of ground surface and station caused by shield cutting diaphragm wall of station

Yantu gongcheng xuebao
This paper takes the project of Tianjin Metro shield cutting the existing station's diaphragm walls as the background. Through on-site monitoring, theoretical analysis and other methods, it deeply studies the variation laws of the vertical displacements ...
LIU Jingjin1, 2, , HUANG Jin1, SUN Jibin 1, 2, JIANG Tuo 3, 4, ZHANG Ze 3, 4, JIANG Kai 3, 4, CHENG Xuesong 1, 2
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Bayesian Network-Driven Risk Assessment and Reinforcement Strategy for Shield Tunnel Construction Adjacent to Wall–Pile–Anchor-Supported Foundation Pit

Buildings
With the increasing demand for urban rail transit capacity, shield tunneling has become the predominant method for constructing underground metro systems in densely populated cities.
Yuran Lu, Bin Zhu, Hongsheng Qiu
doaj   +1 more source

A New Modified Peck Formula for Predicting the Surface Settlement Based on Stochastic Medium Theory

Advances in Civil Engineering, 2019
Peck method and stochastic medium method are the two most commonly used methods to estimate surface settlement caused by tunnel excavation. However, the Peck method was not suitable for a shallow-buried tunnel, and the calculation process of the ...
Zhanping Song, Xiaoxu Tian, Yuwei Zhang
doaj   +1 more source

Ground Settlement of Deeply Buried Two-Lane Tunnels with Large Cross-Sections Using Different Construction Methods

Applied Sciences, 2022
To ensure the safety of excavations such as large section tunnels of the Guangxi Liubin Highway Tunnel Project, we implemented a simulation analysis of 3D tunnel models based on finite software for different construction methods.
Yugang Han, Changming Wei, Mengyuan Cui, Hong Xie, Yangwang Ou, Hao Zhu, Taoying Liu   +6 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Research on historical deformation and rock layer water content variation in large open-pit mining areas based on SBAS and MatDEM

Frontiers in Earth Science
In order to study the characteristics of settlement and deformation evolution of large open pit to underground mine quarries in China, and to analyse the changing law of volumetric water content of overburden rock layers at different mining stages. Based
Jiabo Geng, Jiabo Geng, Cunyang Liu, Cunyang Liu, Cunyang Liu, Xiang Lan, Yunmin Wang, Xing Wang, Xiaobing Wang   +8 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Influence Mechanisms of Earth Pressure Balance Shield Tunneling Parameters on Chamber Pressure and Surface Settlement: A Theoretical and FDM-DEM Coupled Analysis

Applied Sciences
In earth pressure balance (EPB) shield tunneling, chamber pressure control is essential for maintaining excavation-face stability and limiting surface settlement.
Weiguo He, Yang Luo, Yong Yu, Yaming Zhang, Tengfei Li, Wenjun Liu, Yijie Zhang   +6 more
doaj   +1 more source