Results 51 to 60 of about 4,830,776 (306)

Natural environment and human settlement in later prehistoric central Europe [PDF]

open access: yes, 2004
This work analyses the adaptive relationship between early farming settlement and natural environment in Central Europe between 3500 (cal.) BC and AD 400.
Albert, Bruce Michael Worthington
core  

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

Analysis and research on vertical displacement of ground surface and station caused by shield cutting diaphragm wall of station

open access: yesYantu gongcheng xuebao
This paper takes the project of Tianjin Metro shield cutting the existing station's diaphragm walls as the background. Through on-site monitoring, theoretical analysis and other methods, it deeply studies the variation laws of the vertical displacements ...
LIU Jingjin1, 2, , HUANG Jin1, SUN Jibin 1, 2, JIANG Tuo 3, 4, ZHANG Ze 3, 4, JIANG Kai 3, 4, CHENG Xuesong 1, 2
doaj   +1 more source

Numerical modeling of tunneling induced ground deformation and its control [PDF]

open access: yesInternational Journal of Mining and Geo-Engineering, 2016
Tunnelling through cities underlain by soft soil, commonly associated with soil movement around the tunnels and subsequent surface settlement. The predication of ground movement during the tunnelling and optimum support pressure could be based on ...
V B Maji, Abite Adugna
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

Surface settlements caused by shield construction of gas-bearing soils based on column hole shrinkage theory

open access: yesYantu gongcheng xuebao
Relying on the actual project of Hangzhou Metro Tangqing Line shield crossing the gas-bearing stratum, the column hole shrinkage theory is modified, and the formula for calculating the surface settlement caused by the construction of the shield structure
DING Zhi 1, 2, 3, PENG Shaojie 1, ZHANG Xiao 1, XU Jiaoming 2, WEI Xinjiang 2
doaj   +1 more source

A New Modified Peck Formula for Predicting the Surface Settlement Based on Stochastic Medium Theory

open access: yesAdvances in Civil Engineering, 2019
Peck method and stochastic medium method are the two most commonly used methods to estimate surface settlement caused by tunnel excavation. However, the Peck method was not suitable for a shallow-buried tunnel, and the calculation process of the ...
Zhanping Song, Xiaoxu Tian, Yuwei Zhang
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

open access: yesFEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Ground Settlement of Deeply Buried Two-Lane Tunnels with Large Cross-Sections Using Different Construction Methods

open access: yesApplied Sciences, 2022
To ensure the safety of excavations such as large section tunnels of the Guangxi Liubin Highway Tunnel Project, we implemented a simulation analysis of 3D tunnel models based on finite software for different construction methods.
Yugang Han   +6 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

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