Results 71 to 80 of about 4,830,776 (306)

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Settlement Agreement - 2012 Place Holder

, 2012
Settlement Agreement sent to Interior April 2012Settlement Agreement sent to Interior April ...
Settlement Parties
core  

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Prediction method for ground surface settlement induced by bias tunnel based on stochastic medium theory

Yantu gongcheng xuebao
The disturbance of the surrounding soil by tunnel excavation will inevitably lead to surface settlement. When calculating the surface settlement caused by tunnel excavation, various prediction methods have assumed that the tunnel convergence mode is ...
ZHOU Pengyuan 1, 2, SONG Zhanping 1, 2, 3, WANG Junbao 1, 2, ZHANG Yuwei 1, 2, 3, TIAN Xiaoxu 1, 2
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Parameters Modification of Peck Formula for Surface Settlement of Shield Tunnelling in Luoyang [PDF]

Zhengzhou Daxue xuebao. Gongxue ban
In order to accurately predict the surface settlement of the shield tunnel in the silty clay and sand gravel composite formation in Luoyang, a linear regression fitting method was proposed.
GAO Xinjun, WEI Wenyu, LI Shanshan, SU Qinghui   +3 more
doaj   +1 more source

Effect of surface interactions on the settlement of particles on a sinusoidally corrugated substrate

RSC Advances, 2020
The interplay among the surface modulus, geometry, and interactions between the surface and the particle governs particle settlement on sinusoidally-corrugated substrates.
Shreya Erramilli, Taylor V. Neumann, Daniel Chester, Michael D. Dickey, Ashley C. Brown, Jan Genzer   +5 more
openaire   +3 more sources

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Settlement risk under gross and net settlement [PDF]

Previous comparative analyses of gross and net settlement have focused on the credit risk of the central counterparty in net settlement arrangements and on the incentives for participants to alter the risk of the portfolio under net settlement.
Charles M. Kahn, William Roberds, James McAndrews   +2 more
core  

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source