Results 91 to 100 of about 8,336,956 (337)

Shallow tunneling's impact on surface settlements

The Journal of Engineering and Exact Sciences
The research described in this paper deals with the impact of shallow tunneling on surface settlements in urban areas. The study focuses on carrying out a numerical analysis and a parametric geotechnical study to investigate the effects of tunnel excavation on the surface ground, particularly with regard to distortion and potential damage to structures
Mohamed Djenane, Kamel Bezih
openaire   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Surface settlement modelling using neural network

, 2022
Due to land shortage and rapid urbanization, most countries tap on underground resources to optimize land use. This allows valuable surface land to be used for livable uses and reduces the negative impact on city living.
Thung, Jia Hui
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Relief in Aeolian Environment. The Surface of Nida Settlement

Archaeologia Lituana, 2019
During archaeological investigations in Nida settlement in 1974–1978, 2011–2013 and 2016 a lot of stratigraphic data from considerably wide area was gathered. Based on stratigraphy Neolithic paleosol of Nida settlement can be distinguished and it can be used as proxy for reconstruction of paleorelief.
Mindaugas Pilkauskas, Gytis Piličiauskas, Rokas Vengalis   +2 more
openaire   +3 more sources

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Prediction method for ground surface settlement induced by bias tunnel based on stochastic medium theory

Yantu gongcheng xuebao
The disturbance of the surrounding soil by tunnel excavation will inevitably lead to surface settlement. When calculating the surface settlement caused by tunnel excavation, various prediction methods have assumed that the tunnel convergence mode is ...
ZHOU Pengyuan 1, 2, SONG Zhanping 1, 2, 3, WANG Junbao 1, 2, ZHANG Yuwei 1, 2, 3, TIAN Xiaoxu 1, 2
doaj   +1 more source

Pecos River Carlsbad Settlement agreement [PDF]

, 2006
Presented at Ground water and surface water under stress: competition, interaction, solutions: a USCID water management conference on October 25-28, 2006 in Boise, Idaho.The Pecos River Decision Support System (PRDSS) is a complex set of hydrologic ...
Barroll, Peggy, author, McCord, Jim, author, Elhassan, Ali, author, Carron, John, author, U.S. Committee on Irrigation and Drainage, publisher   +4 more
core  

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source