Results 81 to 90 of about 8,336,956 (337)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Surface settlement modelling using neural network 1

, 2021
Ground movement control during tunnelling in urban areas has always been a key concern, as geotechnical engineers strive to minimize any disturbance to nearby buildings and services. Previous studies concerning surface settlement were conducted based on
Tan, Jerie-Ann
core  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Development of surface settlement under the combined effect of foundation pit dewatering and excavation: Insights from experimental modelling

Underground Space
To investigate surface settlement under the combined effect of foundation pit dewatering and excavation, a series of experiments was conducted using a scaled model of a deep foundation pit at a metro station.
Kai-Fang Yang, Min-Liang Chi, Chang-Jie Xu, Chao-Feng Zeng, Lu-Jv Liang, Zhi Ding, Ya-Shi Qiu   +6 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Surface Enhancement of Titanium-Based Coatings on Commercial Hard Steel Cutting Tools

Crystals
This study investigates the mechanical properties, surface integrity, and chemical configuration of PVD-coated high-speed steel (HSS) cutting tools, with a particular focus on titanium nitride (TiN) and titanium aluminium nitride (TiAlN) coatings.
Minh Nhat Dang, Surinder Singh, Hannah J. King, John H. Navarro-Devia, Hoang Le, Thomas G. Pattison, Rosalie K. Hocking, Scott A. Wade, Guy Stephens, Angelo Papageorgiou, Armando Manzano, James Wang   +11 more
doaj   +1 more source

The effect of suction on ground surface settlement for a tunnel [PDF]

E3S Web of Conferences, 2019
This paper addresses the physical modelling of a tunnel for saturated and unsaturated sand as well as tests in dry condition. A series of tests were conducted for a 50 mm diameter tunnel buried 25 mm into a poorly graded fine sand under different normal stresses: 0.78, 1.56, 2.34 and 3.31 kPa.
openaire   +2 more sources

Maximum surface settlement prediction in EPB TBM tunneling using soft computing techniques

, 2021
Earth pressure balance (EPB) TBMs are commonly used for soft ground tunneling in urban areas. In metro tunnels’ excavation, designing a comprehensive monitoring system to control surface settlement is essential to prevent damage to surface structures ...
H. Samadi, J. Hassanpour, E. Farrokh
semanticscholar   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source