Results 61 to 70 of about 4,830,776 (306)

Seismic Suitability Assessment of Steel Slag–Rubber Composite Backfill for Geogrid-Reinforced Retaining Walls

Buildings
The use of recycled steel slag and tire-derived rubber as a combined backfill for geogrid-reinforced retaining walls offers a potential resource-recovery route, yet its influence on seismic performance has not been systematically quantified.
Chenfeng Zong, Zhongyang Mao, Yuhui Zhang, Yangyang Sun   +3 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Influence Mechanisms of Earth Pressure Balance Shield Tunneling Parameters on Chamber Pressure and Surface Settlement: A Theoretical and FDM-DEM Coupled Analysis

Applied Sciences
In earth pressure balance (EPB) shield tunneling, chamber pressure control is essential for maintaining excavation-face stability and limiting surface settlement.
Weiguo He, Yang Luo, Yong Yu, Yaming Zhang, Tengfei Li, Wenjun Liu, Yijie Zhang   +6 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Surface Enhancement of Titanium-Based Coatings on Commercial Hard Steel Cutting Tools

Crystals
This study investigates the mechanical properties, surface integrity, and chemical configuration of PVD-coated high-speed steel (HSS) cutting tools, with a particular focus on titanium nitride (TiN) and titanium aluminium nitride (TiAlN) coatings.
Minh Nhat Dang, Surinder Singh, Hannah J. King, John H. Navarro-Devia, Hoang Le, Thomas G. Pattison, Rosalie K. Hocking, Scott A. Wade, Guy Stephens, Angelo Papageorgiou, Armando Manzano, James Wang   +11 more
doaj   +1 more source

Experimental Investigation of the Performance of Buried Flexible Pipe in Reinforced Sand

Slovak Journal of Civil Engineering, 2023
The experimental work of this study deals with the performance of pipe in sand with various responses subjected to incremental static loading where the backfill is reinforced with two types of reinforcement (geogrid and geocell) to investigate the ...
Fattah Mohammed Y., Zbar Bushra S., Al-Kalali Hala H. M.   +2 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

The effect of suction on ground surface settlement for a tunnel [PDF]

E3S Web of Conferences, 2019
This paper addresses the physical modelling of a tunnel for saturated and unsaturated sand as well as tests in dry condition. A series of tests were conducted for a 50 mm diameter tunnel buried 25 mm into a poorly graded fine sand under different normal stresses: 0.78, 1.56, 2.34 and 3.31 kPa.
openaire   +2 more sources