Results 51 to 60 of about 6,728,043 (242)

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

open access: yesFEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Influence of substrate moisture preparation on concrete overlay bond strength [PDF]

open access: yes, 2014
Includes bibliographical references.A considerable amount of progress has been made over the years in understanding the fundamentals of concrete composition and performance in both safe and harsh environments.
Talotti, Marco
core   +1 more source

Comparative evaluation of compressive strength and surface detail reproducibility of type II and type III gypsum cast materials after sterilization by microwave irradiation: An in-vitro study

open access: yesSaudi Journal of Oral Sciences
Introduction: Gypsum casts are a potential source of cross-contamination between the clinical and laboratory settings, while various disinfection methods have been used to overcome this situation.
R. Sandhya Rani   +8 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

open access: yesMolecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder   +10 more
wiley   +1 more source

Effect of Four Surface Treatment Methods on the Shear Bond Strength of Resin Cement to Zirconia Ceramics- A Comparative in Vitro Study [PDF]

open access: yesJournal of Clinical and Diagnostic Research, 2014
Background: Improving the retention of zirconia-based ceramics is desirable in order to avoid the failure of crowns and fixed partial dentures .This can be achieved by creating micromechanical retention using surface treatments. Therefore, it becomes
Varsha Murthy   +3 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Influences of manufacturing process parameters on interfacial strength in an additive manufactured ABS-resin/Al-alloy dissimilar joint

open access: yesNihon Kikai Gakkai ronbunshu, 2020
In order to develop novel direct manufacturing of ABS resin on Al alloy surface by the 3D printing technique with high interfacial strength, the influences of the temperature and the roughness of the Al-alloy substrate, and the cooling rate after ...
Yasuhiro YAMAZAKI   +3 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Shear Strength Test of UHPC-NC Bonding Surface

open access: yesZhongwai Gonglu
As a cement-based composite material with excellent mechanical properties, ultra-high performance concrete (UHPC) demonstrates outstanding performance in tensile and compressive strength, durability, and impermeability.
ZHANG Shichang   +4 more
doaj   +1 more source

Spatial biology in cancer epigenetics

open access: yesMolecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Home - About - Disclaimer - Privacy