Results 61 to 70 of about 1,124,591 (305)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Modelling of bubble nucleation in trachy-phonolitic magmas: implications for the dynamics of ash-rich eruptions [PDF]

, 2012
Nucleation of water gas bubbles in trachyphonolitic magmatic melts has been investigated integrating theory and numerical modelling with decompression experiments and analysis of natural ash samples of explosive eruptions.
Colucci, Simone
core   +1 more source

Off-equilibrium surface tension in colloidal suspensions

, 2013
We study the fingering instability of the interface between two miscible fluids, a colloidal suspension and its own solvent. The temporal evolution of the interface in a Hele-Shaw cell is found to be governed by the competition between the non-linear ...
Cipelletti, Luca, Dupas, Christelle, Mora, Serge, Truzzolillo, Domenico   +3 more
core   +4 more sources

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Density and Temperature Dependencies of Liquid Surface Tension [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 2011
In this paper the density and temperature dependencies of surface tension are investigated. Using the Lennard-Jones (12,6), as an effective pair interaction potential, a linear expression is derived for isotherms of g /r2  versus r2 for some normal and ...
Haniyeh Alizadeh Osgouei, Gholam Abbas Parsafar, Hamed Akbarzadeh   +2 more
doaj  

Prediction of Surface Tension and Surface Properties of binary mixtures Containing Ionic Liquids Using Thermodynamics and Artificial Neural Network Models [PDF]

شیمی کاربردی روز, 2017
In this paper, surface tension and surface properties of binary mixtures containing alcohol (methanol and ethanol) ionic liquid (1-bptf, 1-b-3-mptf and 1-b-4-mptf)) have been determined using thermodynamics and theoretical methods at various temperatures
احمد باقری, میترا همتیان, سیده مریم سجادی   +2 more
doaj   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Insect-Inspired Wall-Climbing Robots Utilizing Surface Tension Forces

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2010
This paper describes insect-inspired wall-climbing robot that is capable of walking on a smooth vertical surface utilizing surface tension forces. The adhesion mechanism of the robot is inspired from the attachment system of ants, which is responsible ...
Kenji SUZUKI, Shusuke NEMOTO, Takahiro FUKUDA, Hideaki TAKANOBU, Hirofumi MIURA   +4 more
doaj   +1 more source