Results 61 to 70 of about 2,197,659 (258)
Applied Sciences, 2017 This article presents the microstructural evolution within the interphase between a hardening overlay made of cement mortar and an existing concrete substrate.
Łukasz Sadowski, Damian Stefaniuk
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FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
A short review of modification techniques for titanium dental implant surfaces
Current Directions in Biomedical EngineeringIn the world of dental implants, the essential determinant of success lies in the phenomenon of osseointegration, wherein titanium implants exhibit the ability for robust integration with the surrounding bone and tissue.
Oezcelik Sude, Haeger Andreas
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Applied SciencesThe purpose of this study was to investigate the effect of silane treatment of a resin-coated resin-based composite (RBC) base material on its microtensile bond strength (μTBS) to a computer aided-design/computer-aided manufacturing (CAD/CAM) ceramic ...
Akiko Haruyama +2 more
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Science and Engineering of Composite Materials, 2018 This experimental study was conducted to investigate the effect of NaOH concentration and treatment time on the flexural properties of Luffa cylindrica fiber-reinforced epoxy composites.
Mohanta Niharika, Acharya Samir K.
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Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source