Results 31 to 40 of about 1,775,266 (219)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Direct vegetation response to recent CO2 rise shows limited effect on global streamflow

Nature Communications
Global streamflow, crucial for ecology, agriculture, and human activities, can be influenced by elevated atmospheric CO2 (eCO2) though direct regulation of vegetation physiology and structure, which can either decrease or increase streamflow.
Haoshan Wei, Yongqiang Zhang, Qi Huang, Francis H. S. Chiew, Jinkai Luan, Jun Xia, Changming Liu   +6 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Using station-pair to elucidate the cooling effect of vegetation in megacities

Scientific Reports
The air urban heat island (UHI) poses significant challenges to urban environments. While vegetation is a recognized mitigation strategy, the in-situ cooling effects of different vegetation types, such as forests and grasslands, across diverse climatic ...
Zixuan Tang, Jing Tian, Yongqiang Zhang, Junlong Zhang, Xuanze Zhang, Ning Ma   +5 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Contribution of channel geometry adjustments to stage variance based on rating-curves in the main stream of the Lancang–Mekong river

Scientific Reports
Extensive dam development and climate change have altered seasonal stage variation patterns, which are critical to residents in the riparian zone along the Lancang–Mekong River.
Li He, Qiuhong Tang, Dong Chen, Paul P. J. Gaffney, Gaohu Sun   +4 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Morphological Response to Sub-Seasonal Hydrological Regulation in the Yellow River Mouth: A 1996–2023 Case Study

Hydrology
River flow has historically been the primary force shaping the morphology of the Yellow River estuary. However, since the Xiaolangdi Reservoir began operating in 2000, the hydrological processes reaching the estuary have been significantly modified.
Jingjing Zhu, He Qing Huang, Guo-An Yu, Weipeng Hou, Xiao Zhao, Xueqin Zhang   +5 more
doaj   +1 more source