Results 51 to 60 of about 2,251,096 (285)
HydrologyRiver flow has historically been the primary force shaping the morphology of the Yellow River estuary. However, since the Xiaolangdi Reservoir began operating in 2000, the hydrological processes reaching the estuary have been significantly modified.
Jingjing Zhu +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Water scarcity under various socio-economic pathways and its potential effects on food production in the Yellow River basin [PDF]
Hydrology and Earth System Sciences, 2017 Increasing population and socio-economic development have put great pressure on water resources of the Yellow River (YR) basin. The anticipated climate and socio-economic changes may further increase water stress.
Y. Yin, Q. Tang, X. Liu, X. Zhang
doaj +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Remote SensingGroundwater storage is vital for managing water resources, especially as global water scarcity intensifies. Estimating groundwater levels regionally is challenging due to natural heterogeneity.
Yijing Cao +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
2004 integrated water quality monitoring and assessment report
, 2004 Title from Web page, last updated 21 May 2004 (viewed Dec. 28, 2004).; Harvested from the web on 11/23/05This report indicates the general condition of Ohio's waters and identifies waters that are not meeting water quality goals.This report indicates the
Ohio EPA. Division of Surface Water.
core
AbstractThis chapter assesses surface water changes due to climate change and human activities, by particularly examining runoff and streamflow. Changes in the hydrological cycle due to climate change and human intervention can lead to diverse environmental impacts and risks.
Junguo Liu +9 more
openaire +2 more sources