Results 61 to 70 of about 2,251,096 (285)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Integrated water quality monitoring and assessment report, Ohio 2002

, 2002
Title from web page.; "Prepared to fulfill the requirements of Sections 305(b) and 303(d) of the Clean water Act."; "October 1, 2002, final for U.S.
Ohio EPA.Division of Surface Water.
core  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Biological and water quality study of Big Darby Creek and selected tributaries, 2001/2002 : Logan, Champaign, Union, Madison, Franklin and Pickaway counties, Ohio.

, 2004
Title from home page (viewed on Aug. 23, 2006).; "Prepared by State of Ohio Environmental Protection Agency, Division of Surface Water ..."--PDF t.p.; "June 28, 2004."; Harvested from the web on 8/23 ...
Ohio EPA. Division of Surface Water.
core  

National water planning report card 2013 [PDF]

, 2014
Provides a summary of the status of water plans across Australia. Executive Summary This National Water Planning Report Card 2013 follows the first baseline assessment undertaken in 2011.

core  

Environmental flow assessment, evaluation, and suggestions for dying riverine ecosystem of the transboundary Amudarya River, Central Asia

Ecological Indicators
The Amudarya River (ADR) is the largest source of freshwater in Central Asia providing livelihood to millions of people by extracting water for agriculture. However, the over-exploitation has created some critical environmental issues.
Rashid Mahmood, Shaofeng Jia, Aifeng Lv, Shahid Naeem   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Causes & sources of impairment, year 2000

, 2000
Title from web page.; Harvested from the web on 2/7 ...
Ohio EPA.Division of Surface Water.
core  

A global drought dataset for Multivariate Composite Drought Index (MCDI) and its constituent drought indices

Scientific Data
High-resolution drought index datasets are essential for drought monitoring and assessment. Despite numerous global/regional drought index datasets, the composite drought index datasets that comprehensively consider meteorological, agricultural, and ...
Mengjia Yuan, Guojing Gan, Jingyi Bu, Yanxin Su, Hongyu Ma, Xianghe Liu, Leyao Zhang, Yongqiang Zhang, Yanchun Gao   +8 more
doaj   +1 more source

Review of Research on the Present Situation of Development and Resource Potential of Wind and Solar Energy in China

Energies
To address the global warming issue, China is prioritizing the development of clean energy sources such as wind and solar power under its “dual carbon target”.
Taohui Li, Yonghao Liu, Aifeng Lv
doaj   +1 more source