Results 61 to 70 of about 5,049,215 (291)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Shuiwen dizhi gongcheng dizhi, 2023 Fresh groundwater lenses are important resources for local inhabitants and ecosystems in coral islands. In view of the complexity of the coral islands, it is necessary to seek the measures of low-cost, effective and less impact on the stability and the ...
Yinghao LI +4 more
doaj +1 more source
Non-linear macro evolution of a dc driven micro atmospheric glow discharge
, 2015 We studied the macro evolution of the micro atmospheric glow discharge generated between a micro argon jet into ambient air and static water. The micro discharge behaves similarly to a complex ecosystem.
Xu, Shaofeng, Zhong, Xiaoxia
core +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
HydrologyRiver flow has historically been the primary force shaping the morphology of the Yellow River estuary. However, since the Xiaolangdi Reservoir began operating in 2000, the hydrological processes reaching the estuary have been significantly modified.
Jingjing Zhu +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Water scarcity under various socio-economic pathways and its potential effects on food production in the Yellow River basin [PDF]
Hydrology and Earth System Sciences, 2017 Increasing population and socio-economic development have put great pressure on water resources of the Yellow River (YR) basin. The anticipated climate and socio-economic changes may further increase water stress.
Y. Yin, Q. Tang, X. Liu, X. Zhang
doaj +1 more source
Surface Tension of Electrolyte Solutions: A Self-consistent Theory
, 2014 We study the surface tension of electrolyte solutions at the air/water and oil/water interfaces. Employing field-theoretical methods and considering short-range interactions of anions with the surface, we expand the Helmholtz free energy to first-order ...
Andelman, David +2 more
core +1 more source
Sign of the Casimir-Polder interaction between atoms and oil-water interfaces: Subtle dependence on dielectric properties [PDF]
, 2012 We demonstrate that Casimir-Polder energies between noble gas atoms (dissolved in water) and oil-water interfaces are highly surface specific. Both repulsion (e.g. hexane) and attraction (e.g. glycerine and cyclodecane) is found with different oils.
B. W. Ninham +12 more
core +2 more sources
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source