Results 71 to 80 of about 92,151 (207)

Influence of East and South Asian summer monsoons on runoff in the monsoon region of East China

Shui kexue jinzhan, 2016
The Variable Infiltration Capacity (VIC) model and the Mann-Kendall with LOWESS test are employed to evaluate the influence of East Asian summer monsoon (EASM) and South Asian summer monsoon (SASM) on runoff in the monsoon region of East China.
LI Fuxing, CHEN Dong, TANG Qiuhong, YAN Yunxia   +3 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Localized Browning in Thermokarst-Dominated Landscapes Reverses Regional Greening Trends Under a Warming Climate in Northeastern Siberia

Remote Sensing
The response of Arctic vegetation to climate warming exhibits pronounced spatial heterogeneity, driven partly by widespread permafrost degradation. However, the role of thermokarst lake development in mediating vegetation-climate interactions remains ...
Ruixin Wang, Ping Wang, Li Xu, Shiqi Liu, Qiwei Huang   +4 more
doaj   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Evaluating the impact of soil erosion on soil quality in an agricultural land, northeastern China

Scientific Reports
The impact of soil erosion on soil quality is still not systematically understood. The purpose of this study was thus to quantify the impact of soil erosion on soil quality and its change with slope morphology in an agricultural field, northeastern China
Haiyan Fang, Yuyu Zhai, Chaoyue Li
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Porewater salinity reveals past lake-level changes in Lake Van, the Earth’s largest soda lake

Scientific Reports, 2017
In closed-basin lakes, sediment porewater salinity can potentially be used as a conservative tracer to reconstruct past fluctuations in lake level. However, until now, porewater salinity profiles did not allow quantitative estimates of past lake-level ...
Yama Tomonaga, Matthias S. Brennwald, David M. Livingstone, Olga Kwiecien, Marie-Ève Randlett, Mona Stockhecke, Katie Unwin, Flavio S. Anselmetti, Jürg Beer, Gerald H. Haug, Carsten J. Schubert, Mike Sturm, Rolf Kipfer   +12 more
doaj   +1 more source