Results 31 to 40 of about 5,943,631 (302)

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Laparoscopic versus open colorectal resection for cancer and polyps: A cost-effectiveness study [PDF]

, 2014
Methods: Participants were recruited in 2006-2007 in a district general hospital in the south of England; those with a diagnosis of cancer or polyps were included in the analysis.
Dowson, H, Gage, H, Jackson, D, Jordan, J, Rockall, T   +4 more
core   +1 more source

Adherence to Protocol Recommendations for Children With Wilms Tumour in Two Consecutive Studies in the United Kingdom and Ireland—Does Variation Matter?

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Aims Wilms tumour (WT) has excellent event‐free and overall survival (OS). However, small differences exist between countries participating in the same international study. This led us to examine variation in adherence to protocol recommendations as a potential contributing factor.
Suzanne Tugnait, R. Al‐Saadi, A. Lopez‐Cortes, K. Dzhuma, M. Oostveen, J. Brok, S. Irtan, M. Weeks, J. Bate, S. Baker, R. Williams, M. Powis, D. Saunders, O. Olsen, T. Watson, S. Shelmerdine, S. Vaidya, L. Howell, C. Duncan, G. M. Vujanic, C. Stiller, G. P. Balchin, T. Chowdhury, K. Pritchard‐Jones   +23 more
wiley   +1 more source

Safety of overlapping inpatient orthopaedic surgery: A multicenter study [PDF]

, 2018
BackgroundAlthough overlapping surgery is used to maximize efficiency, more empirical data are needed to guide patient safety. We conducted a retrospective cohort study to evaluate the safety of overlapping inpatient orthopaedic surgery, as judged by the
Dy, Christopher J, Gottschalk, Michael B, Maak, Travis G, Maloney, Michael D, O\u27Keefe, Regis J, Osei, Daniel A, Presson, Angela P, Zhang, Alan L   +7 more
core   +1 more source

Lens spaces obtainable by surgery on doubly primitive knots

, 2007
In this paper, we consider which lens spaces are obtainable by Dehn surgery described by Berge on doubly primitive knots. It is given an algorithm to decide whether a given lens space is obtainable by such surgery.
Burde, Homma, Kazuhiro Ichihara, Kirby, Montesinos, Moser, Saito, Toshio Saito   +7 more
core   +3 more sources

An examination of who is eligible and who is receiving bariatric surgery in England : secondary analysis of the Health Survey for England dataset [PDF]

, 2019
Background: Over 2 million people in England were estimated to be eligible for bariatric surgery in 2006. In 2014, clinical guidelines were updated, widening potential eligibility, meanwhile, obesity prevalence rose.
Desogus, Daniel, Menon, Vinod, Singhal, Rishi, Oyebode, Oyinlola   +3 more
core   +1 more source

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson, Ingrid Winship, Gary Hammerschlag, Laura Scardamaglia   +3 more
wiley   +1 more source

Expert Consensus on Community Management of Diagnosis and Treatment of Osteoarthritis and Osteoporosis in the Elderly (Version 2023)

Xiehe Yixue Zazhi, 2023
The prevalence of osteoarthritis (OA) and osteoporosis (OP) in China is increasing every year and they are often co-affected, seriously affecting the health and quality of life of elderly people.
Joint Surgery Group of Beijing Medical Association Orthopaedic Branch
doaj   +1 more source

Influence of surgery and rehabilitation conditioning on psychophysiological fitness [PDF]

, 2008
The purpose of this study was to assess changes in psychophysiological fitness following reconstructive knee surgery and early phase (2.5 months) physical rehabilitation. Nine patients (7 male, 2 female; mean age, 29.9 years) electing to undergo anterior
Bailey, A, Gleeson, N, Minshull, C, Parfitt, G, Rees, D   +4 more
core  

Intravitreal GD2‐Specific Chimeric Antigen Receptor T‐Cell Therapy for Refractory Retinoblastoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Effective treatments for advanced, treatment‐resistant retinoblastoma (RB) remain limited. GD2‐specific chimeric antigen receptor (CAR) T cells show potent antitumor activity with minimal toxicity but have not previously been evaluated in RB.
Subongkoch Subhadhirasakul, Jatuporn Sujjitjoon, Pa‐thai Yenchitsomanus, Kridtin Jarutatsanangkoon, Ng Wei Loon, Kleebsabai Sanpakit, Jassada Buaboonnam, Chayamon Takpradit, Pornpimon Yuti, Nunghathai Sawasdee, Piriya Luangwattananun, Siripakorn Sangkitporn, Arnan Limmahachai, La‐ongsri Atchaneeyasakul   +13 more
wiley   +1 more source