Results 41 to 50 of about 3,437,604 (263)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Exploration and Validation of Key Genes and Immune Infiltration in Alcoholic Hepatitis
Journal of Inflammation ResearchYingna Mei,1 Yitao Zheng,2 Xingfen Zhang,1 Ting Hu,1 Xiaoqing Zheng,1 Cui Zhang,3 Qinzhi Deng1 1Department of Liver Disease, Ningbo No.2 Hospital, Ningbo, People’s Republic of China; 2Department of Pancreatic and Gastrointestinal Surgery Division, Ningbo
Mei Y +6 more
doaj
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
Risk Management and Healthcare PolicyMohammad Masudi,1,2 Ali Rahimi,1,2 Enayatollah Ejaz,1,2 Khadejah Osmani,3 Nasar Ahmad Shayan4 1Department of Curative Medicine, Faculty of Medicine, Jami University, Herat, Afghanistan; 2Department of Pediatrics, Faculty of Medicine, Herat University ...
Masudi M +4 more
doaj
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
Intraoperative Encounter of a Live Term Abdominal Pregnancy: A Rare Case Report from Rwanda
International Journal of Women's HealthTemesgen Tantu Arusi,1 Samsone Habimana,1 Niyomufasha Daniel,1 Bellarmin Matungo,1 Nsanzimana Paul,1 Harerimana Vedaste,1 Yohanna Hailu,1 Muhuza Marie Parfaite2 1Department of Obstetrics and Gynecology, College of Dental and Medical Sciences, Nyagatare ...
Arusi TT +7 more
doaj
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Patient Preference and AdherenceYanhua Xu,1 Qun Chen,1 Min Wang,2 Yichen Lu3 1Gastrointestinal Surgery Department, The Affiliated Taizhou People’s Hospital of Nanjing Medical University, Taizhou, Jiangsu Province, People’s Republic of China; 2Surgical Department, The Affiliated Taizhou
Xu Y, Chen Q, Wang M, Lu Y
doaj