Results 61 to 70 of about 5,943,631 (302)

Is there overutilisation of cataract surgery in England? [PDF]

, 2009
<b>Objectives:</b> Following a 3.7-fold increase in the rate of cataract surgery in the UK between 1989 and 2004, concern has been raised as to whether this has been accompanied by an excessive decline in the threshold such that some ...
Black, N., Browne, J., Copley, L.P., Jamison, L., Lewsey, J., van der Meulen, J.H.   +5 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Exploration and Validation of Key Genes and Immune Infiltration in Alcoholic Hepatitis

Journal of Inflammation Research
Yingna Mei,1 Yitao Zheng,2 Xingfen Zhang,1 Ting Hu,1 Xiaoqing Zheng,1 Cui Zhang,3 Qinzhi Deng1 1Department of Liver Disease, Ningbo No.2 Hospital, Ningbo, People’s Republic of China; 2Department of Pancreatic and Gastrointestinal Surgery Division, Ningbo
Mei Y, Zheng Y, Zhang X, Hu T, Zheng X, Zhang C, Deng Q   +6 more
doaj  

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Assessment of Hand Hygiene Knowledge, Attitude, and Practice Among Health Sciences Students in Herat, Afghanistan: A Cross-Sectional Study [Response to Letter]

Risk Management and Healthcare Policy
Mohammad Masudi,1,2 Ali Rahimi,1,2 Enayatollah Ejaz,1,2 Khadejah Osmani,3 Nasar Ahmad Shayan4 1Department of Curative Medicine, Faculty of Medicine, Jami University, Herat, Afghanistan; 2Department of Pediatrics, Faculty of Medicine, Herat University ...
Masudi M, Rahimi A, Ejaz E, Osmani K, Shayan NA   +4 more
doaj  

Perturbative 3-manifold invariants by cut-and-paste topology

, 1999
We give a purely topological definition of the perturbative quantum invariants of links and 3-manifolds associated with Chern-Simons field theory. Our definition is as close as possible to one given by Kontsevich.
Kuperberg, Greg, Thurston, Dylan P.
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Intraoperative Encounter of a Live Term Abdominal Pregnancy: A Rare Case Report from Rwanda

International Journal of Women's Health
Temesgen Tantu Arusi,1 Samsone Habimana,1 Niyomufasha Daniel,1 Bellarmin Matungo,1 Nsanzimana Paul,1 Harerimana Vedaste,1 Yohanna Hailu,1 Muhuza Marie Parfaite2 1Department of Obstetrics and Gynecology, College of Dental and Medical Sciences, Nyagatare ...
Arusi TT, Habimana S, Daniel N, Matungo B, Paul N, Vedaste H, Hailu Y, Parfaite MM   +7 more
doaj  

Algebraic Poincare cobordism [PDF]

, 2000
This paper is an introduction to the use of the cobordism of chain complexes with Poincar\'e duality in surgery theory. It is a companion to the author's paper "An introduction to algebraic surgery" math.AT/0008071 (to appear in Volume 2 of Surveys in ...
Ranicki, Andrew
core   +1 more source

Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion

Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana, Mariana Maschietto, Daniela Paz Leal, Ricardo de Santos de Oliveira, Mayara Ferreira Euzébio, Antonio Carlos dos Santos, Luciano Neder, Carlos Alberto Scrideli, Elvis Terci Valera   +8 more
wiley   +1 more source