Results 121 to 130 of about 18,299 (267)

Targeting KRAS for cancer therapy

British Journal of Pharmacology, EarlyView.
In recent years, therapeutics targeted against KRAS proto‐oncogene GTPase (KRAS)‐mutant cancers have seen significant progress. Herein we outline the biology and epidemiology of KRAS alterations at the lineage and allele levels, reviewing the clinical evidence for KRASG12C inhibition from the discovery of the recessive switch pocket to sotorasib ...
Jianlong Jia, Ruonan Liu, Tonia A. Adamide, Isis E. Fernandez, Georgios T. Stathopoulos   +4 more
wiley   +1 more source

Piglets' acute responses to local anesthetic injection and surgical castration: Effects of the injection method and interval between injection and castration. [PDF]

Front Vet Sci, 2022
Coutant M, Malmkvist J, Kaiser M, Foldager L, Herskin MS.   +4 more
europepmc   +1 more source

Hypericin Suppresses Liver Cancer Through Autophagic Degradation of AKT and Eliciting Antitumor Immune Response

Cancer Science, EarlyView.
Hypericin induces autophagic AKT degradation by promoting AKT‐HSPA5 interaction in an S473 phosphorylation‐dependent manner, suppressing HCC growth. It enhances CD8+ T cell‐mediated antitumor immunity and synergizes with anti‐PD‐L1 therapy, showing favorable safety for HCC treatment. ABSTRACT Hepatocellular carcinoma (HCC) is the most prevalent primary
Sien Ma, Qianqian Xu, Mengjuan Zhu, Xianming Ge, Jian Xu, Yan Pan, Mengli Wang, Yuting Zhu, Aoxuan Xu, Hanmeng Liu, GuangHai Xiang, Weipeng Gong, Bao Zhao   +12 more
wiley   +1 more source

Piglets' acute responses to procaine-based local anesthetic injection and surgical castration: Effects of two volumes of anesthetic. [PDF]

Front Pain Res (Lausanne), 2022
Coutant M, Malmkvist J, Kaiser M, Foldager L, Herskin MS.   +4 more
europepmc   +1 more source

‘Fatherhood Under Suspicion’: The Experiences of Fathers of At‐Risk Children From East Jerusalem Following Out‐of‐Home Placement

Child &Family Social Work, EarlyView.
ABSTRACT Fathers, particularly in conservative patriarchal societies and politically complex contexts, are often underrepresented in research on child protection and out‐of‐home placements. Addressing this significant knowledge gap, this study focuses on Palestinian fathers from East Jerusalem whose young children were removed from their homes by court
Mayis Eissa
wiley   +1 more source

Evaluation of Two Injection Techniques in Combination with the Local Anesthetics Lidocaine and Mepivacaine for Piglets Undergoing Surgical Castration. [PDF]

Animals (Basel), 2022
Werner J, Saller AM, Reiser J, Senf S, Deffner P, Abendschön N, Fischer J, Grott A, Miller R, Zablotski Y, Steiger K, Bergmann S, Erhard MH, Ritzmann M, Zöls S, Baumgartner C.   +15 more
europepmc   +1 more source

Surgical Castration [PDF]

, 2020
openaire   +1 more source

Immunocastration as Alternative to Surgical Castration in Pigs [PDF]

, 2017
Čandek-Potokar, M., Škrlep, M., Zamaratskaia, Galia   +2 more
openaire   +2 more sources

Belgian consumers' attitude towards surgical castration and immunocastration of piglets

, 2009
In the vast majority of European countries, piglets are surgically castrated in order to eliminate the risk of boor taint, an odour or flavour that can be present when pork from entire males is cooked.
Verbeke, Wim, Tuyttens, Frank, Vanhonacker, Filiep   +2 more
core   +1 more source

Testicular torsion in foals and stallions

Equine Veterinary Education, EarlyView.
Summary Testicular torsion is a rare condition in horses characterised by a change in the position of the testis due to the testicular mesentery twisting around its own axis; it can occur both when the testis is still in the abdominal cavity and when it has descended into the scrotum.
C. P. Bartmann
wiley   +1 more source