Results 171 to 180 of about 34,275 (269)

The Multifaceted Legacy of Thalidomide: Chemistry and Biology Driving Modern Drug Design

ChemMedChem, Volume 21, Issue 7, 14 April 2026.
Thalidomide serves as a molecular nexus linking chemistry and biology: advances in synthesis and structural understanding enable protein degradation technologies, while its immunomodulatory activity underpins anti‐inflammatory and anticancer therapies.
Konstantina Nikovia, Michael Kapsalis, Michael Georgoulakis, Athanasios Panousis, Constantinos G. Neochoritis   +4 more
wiley   +1 more source

The Effect of Alternative Sheep–Beef Enterprise Mixes on Farm Productivity, Profitability and Predicted Enteric Methane Emissions in North Island Hill Country Farms

New Zealand Journal of Agricultural Research, Volume 69, Issue 2, April 2026.
Sheep or beef cattle (cattle) share of total farm feed consumed, measured in stock units (SU) on New Zealand farms, is often adjusted depending on the profitability of each enterprise. The impact of these adjustments on whole‐farm productivity, profitability and predicted methane (CH4) output has not been recently explored. A system dynamics model of a
Joseph A. Adjabui, Patrick C. H. Morel, Stephen T. Morris, Thiagarajah Ramilan, Peter R. Tozer, Paul R. Kenyon   +5 more
wiley   +1 more source

Antibody–Drug Conjugates in Oncology: Principles, Clinical Development, and Future Directions

MedComm, Volume 7, Issue 4, April 2026.
Antibody–drug conjugates integrate antibody targeting with potent cytotoxic payloads to enable precision cancer therapy. Their clinical performance depends on coordinated optimization of engineering design, tumor antigen biology, and treatment strategy. Lessons from uro‐oncological malignancies illustrate how ADCs can be effectively developed, combined,
Bisheng Cheng, Lanqi Gong, Zongwei Wang, Peidan Peng, Kewei Xu, Hai Huang, Peng Wu   +6 more
wiley   +1 more source

Simple and Epididymal-Sparing Orchiectomy for Surgical Castration in Stage IV Prostate Cancer. [PDF]

Ochsner J
Travis H, Dubic M, Bardot J, Edwards B, Gills JR, Delacroix SE, LaCour S, Mutter M, Bell D, Westerman ME.   +9 more
europepmc   +1 more source

Comparative Digital Estrogen Receptor Alpha (ERα) Expression Analysis in Benign and Malignant Prostate Tissue of Men and Dogs

The Prostate, Volume 86, Issue 5, Page 568-581, April 2026.
ABSTRACT Background The dog is the only large mammal, other than humans, that commonly develops spontaneous prostate cancer (PCa) and is, therefore, considered a valuable model for comparative studies. Estrogens are critical for normal prostate development and contribute to prostatic carcinogenesis in men.
Jennifer Lothion‐Roy, Leonore Aeschlimann, Lea Anna Hiller, Sven Rottenberg, Nigel P. Mongan, Catrin S. Rutland, Emad Rakha, Alexander Dean, Mark A. Rubin, Simone de Brot   +9 more
wiley   +1 more source

Post Hoc Subgroup Analysis of Clinical Outcomes in Patients With High‐Risk Metastatic Hormone‐Naïve Prostate Cancer: Results From a 3‐Year Interim Analysis of the J‐ROCK Study

The Prostate, Volume 86, Issue 5, Page 599-608, April 2026.
ABSTRACT Introduction In real‐world practice in Japan, standard treatment for metastatic hormone‐naïve prostate cancer (mHNPC) is androgen deprivation therapy (ADT), administered as monotherapy, combined androgen blockade (CAB), ADT plus androgen receptor pathway inhibitors (ARPIs), or ADT plus docetaxel.
Atsushi Mizokami, Rikiya Matsumoto, Hideaki Miyake, Hiroji Uemura, Hirotsugu Uemura, Satoru Kawakami, Kazuyoshi Nakamura, Shigekatsu Maekawa, Hiroaki Tsuchiya, Sachie Okazaki, Eri Adachi, Ryo Yano, Yohei Tajima, Kiyohide Fujimoto, Hideyasu Matsuyama   +14 more
wiley   +1 more source

Real-time and video-recorded pain assessment in beef cattle: clinical application and reliability in young, adult bulls undergoing surgical castration. [PDF]

Sci Rep
Tomacheuski RM, de Oliveira AR, Trindade PHE, Lopez-Soriano M, Merenda VR, Luna SPL, Pairis-Garcia MD.   +6 more
europepmc   +1 more source

Post‐Therapeutic Dosimetry of Metastatic Castration‐Resistant Prostate Cancer With 177Lu‐PSMA: Experiences From Two University‐Based Hospitals in Thailand

Asia-Pacific Journal of Clinical Oncology, Volume 22, Issue 2, Page 199-206, April 2026.
ABSTRACT Objective 177Lu‐PSMA radioligand therapy (RLT) is increasingly used to treat metastatic castration‐resistant prostate cancer (mCRPC). Posttreatment dosimetry is essential for assessing normal organ absorbed doses. Therefore, this study aims to evaluate normal organs dosimetry in mCRPC patients undergoing 177Lu‐PSMA‐RLT from two university ...
Onnicha Pattanawong, Putthiporn Charoenphun, Wichana Chamroonrat, Thonnapong Thongpraparn, Nucharee Poon‐iad, Benjapa Khiewvan, Krisanat Chuamsaamarkkee   +6 more
wiley   +1 more source

Surgical versus medical castration in prostate cancer patients [PDF]

Nature Clinical Practice Urology, 2005
openaire   +2 more sources

Letter to the Editor on the surgical castration of piglets [PDF]

Animal, 2009
AngelaJ. Wright, BSc, MSc (Oxon), Martin Whiting, BSc BVetMed MRCVS, Alan Taylor, BSc BVSc CertVA MRCVS   +2 more
openaire   +3 more sources