Results 101 to 110 of about 16,508 (245)

Acute anaphylactic and multiorgan inflammatory effects of Comirnaty in pigs: evidence of spike protein mRNA transfection and paralleling inflammatory cytokine upregulation

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Rare but severe adverse events (AEs) associated with mRNA‐lipid nanoparticle (LNP) COVID‐19 vaccines, such as Comirnaty, include anaphylaxis and inflammatory organ disorders, but their underlying mechanisms are poorly understood. We aimed to develop an animal model to study these phenomena.
László Dézsi, Gábor Kökény, Gábor Szénási, Csaba Révész, Tamás Mészáros, Bálint A. Barta, Réka Facsko, Anna Szilasi, Tamás Bakos, Gergely T. Kozma, Attila B. Dobos, Béla Merkely, Tamás Radovits, János Szebeni   +13 more
wiley   +1 more source

Piglets' acute responses to local anesthetic injection and surgical castration: Effects of the injection method and interval between injection and castration. [PDF]

Front Vet Sci, 2022
Coutant M, Malmkvist J, Kaiser M, Foldager L, Herskin MS.   +4 more
europepmc   +1 more source

The role of macrophage migration inhibitory factor (MIF) in the pathogenesis and progression of cardiovascular disease

British Journal of Pharmacology, EarlyView.
Abstract Cardiovascular disease (CVD) remains the leading global cause of death, driven by complex mechanisms, in which chronic inflammation plays a central role. Inflammatory pathways contribute to all stages of CVD, from endothelial dysfunction and plaque formation to erosion, rupture and myocardial injury.
Shreya Mahabhashyam, James Harris, Jürgen Bernhagen, Antony Vinh, Katrina M. Mirabito Colafella   +4 more
wiley   +1 more source

Piglets' acute responses to procaine-based local anesthetic injection and surgical castration: Effects of two volumes of anesthetic. [PDF]

Front Pain Res (Lausanne), 2022
Coutant M, Malmkvist J, Kaiser M, Foldager L, Herskin MS.   +4 more
europepmc   +1 more source

NRF2/xCT‐Mediated Antioxidant Adaptation Attenuates Apoptosis Induced by ASCT2 Inhibition in Prostate Cancer

Cancer Science, EarlyView.
ASCT2 inhibition induces ROS accumulation and activates NRF2‐dependent xCT upregulation in prostate cancer. This adaptive response partially supports residual cystine acquisition and glutathione synthesis, whereas combined ASCT2 and xCT inhibition disrupts redox compensation and predominantly promotes apoptotic cell death.
Jiaxing Wei, Yasutaka Yamada, Takaaki Tamura, Masahiro Sugiura, Xue Zhao, Meng Ni, Adilan Aierken, Tomokazu Sazuka, Yusuke Imamura, Shinichi Sakamoto   +9 more
wiley   +1 more source

Immunocastration as Alternative to Surgical Castration in Pigs [PDF]

, 2017
Čandek-Potokar, M., Škrlep, M., Zamaratskaia, Galia   +2 more
openaire   +2 more sources

Hypericin Suppresses Liver Cancer Through Autophagic Degradation of AKT and Eliciting Antitumor Immune Response

Cancer Science, EarlyView.
Hypericin induces autophagic AKT degradation by promoting AKT‐HSPA5 interaction in an S473 phosphorylation‐dependent manner, suppressing HCC growth. It enhances CD8+ T cell‐mediated antitumor immunity and synergizes with anti‐PD‐L1 therapy, showing favorable safety for HCC treatment. ABSTRACT Hepatocellular carcinoma (HCC) is the most prevalent primary
Sien Ma, Qianqian Xu, Mengjuan Zhu, Xianming Ge, Jian Xu, Yan Pan, Mengli Wang, Yuting Zhu, Aoxuan Xu, Hanmeng Liu, GuangHai Xiang, Weipeng Gong, Bao Zhao   +12 more
wiley   +1 more source

Evaluation of Two Injection Techniques in Combination with the Local Anesthetics Lidocaine and Mepivacaine for Piglets Undergoing Surgical Castration. [PDF]

Animals (Basel), 2022
Werner J, Saller AM, Reiser J, Senf S, Deffner P, Abendschön N, Fischer J, Grott A, Miller R, Zablotski Y, Steiger K, Bergmann S, Erhard MH, Ritzmann M, Zöls S, Baumgartner C.   +15 more
europepmc   +1 more source

Surgical Castration [PDF]

, 2020
openaire   +1 more source

‘Fatherhood Under Suspicion’: The Experiences of Fathers of At‐Risk Children From East Jerusalem Following Out‐of‐Home Placement

Child &Family Social Work, EarlyView.
ABSTRACT Fathers, particularly in conservative patriarchal societies and politically complex contexts, are often underrepresented in research on child protection and out‐of‐home placements. Addressing this significant knowledge gap, this study focuses on Palestinian fathers from East Jerusalem whose young children were removed from their homes by court
Mayis Eissa
wiley   +1 more source