Results 31 to 40 of about 201,930 (301)

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Workspace Derivation of Arthroscope Using Morphological Data and Standard Portal Placement Method for Shoulder Arthroscopy

IEEE Access, 2021
Robotic arthroscopy is a potential alternative surgery method because the use of robotic arthroscope manipulators could ensure a constant quality of view that would enhance the workflow of the operator. To achieve this advancement, a workspace derivation
Chang-Kyun Kim, Joonhwan Kim, Dongjun Park, Dong-Soo Kwon   +3 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Advances in 3D printing technology for preparing bone tissue engineering scaffolds from biodegradable materials

Frontiers in Bioengineering and Biotechnology
IntroductionBone tissue engineering (BTE) provides an effective repair solution by implanting osteoblasts or stem cells into biocompatible and biodegradable scaffolds to promote bone regeneration.
Zhen Wang, Zhen Wang, Zhen Wang, Yanan Sun, Chen Li   +4 more
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Prototype of the “Universal Tuneller” surgical instrument for extra-projection thyroid and parathyroidectomies [PDF]

, 2023
М. Б. Салиба, I. A. Lychagin, А В Егоров, Ippolitov Li, Vetshev Ps, K. K. Popov   +5 more
openalex   +1 more source

QUALITY OF LIFE OUTCOMES FOLLOWING ULTRASONIC DISSECTOR-ASSISTED VS. ELECTROCAUTERY DISSECTION IN MODIFIED RADICAL MASTECTOMY: PROSPECTIVE OBSERVATIONAL COHORT

Central Asian Journal of Medical Hypotheses and Ethics
Background: Breast cancer is one of the most common malignancies worldwide, with significant implications for patient quality of life (QoL). As survival rates improve, assessing the long-term effects of treatment has become crucial.
Nazgul Dzhantemirova, Marat Mauletbaev, Asiya Kukanova, Aizhan Bekisheva, Abay Makishev   +4 more
doaj   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Can a humid storage environment of surgical instruments before reprocessing increase patient safety and durability of instruments? [PDF]

, 2022
Peter Rubak, Jan Lorenzen, Krister Ripadal, A-E. Christensen, Dorthe Aaen, Hans Linde Nielsen, Karin Bundgaard   +6 more
openalex   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source