Results 71 to 80 of about 4,737,260 (339)

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Factors Related to Recurrence Rates of Extramammary Paget Disease: A Case Series and Literature Review

Archives of Plastic Surgery
Extramammary Paget disease (EMPD) is a rare cutaneous malignant lesion. Surgical resection is the primary treatment. However, the ideal surgical margin remains uncertain.
Boonyaporn Kotistienkul, Nattanit Poungjantaradej, Natthapong Kongkunnavat, Warangkana Tonaree   +3 more
doaj   +1 more source

Correlation between Bladder Neck Preservation, Positive Surgical Margins, and Biochemical Recurrence in Laparoscopic and Open Radical Prostatectomy: A Prospective Cohort Study

Applied Sciences, 2022
Background: Bladder neck preservation (BNP) has been adopted in open (ORP), laparoscopic (LRP), and robot-assisted radical prostatectomy (RARP). However, there are concerns that this technique can compromise oncological outcome and increase positive ...
Boris M. Kajmakovic, Milos Petrovic, Petar Bulat, Uros Bumbasirevic, Bogomir Milojevic, Zoran Bukumiric, Djordje Cvijanovic, Daniel Skrijelj, Aleksandar Jovanovic, Adi Hadzibegovic, Sanja Ratkovic, Zoran Dzamic   +11 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Hyperspectral Imaging of Head and Neck Squamous Cell Carcinoma for Cancer Margin Detection in Surgical Specimens from 102 Patients Using Deep Learning

Cancers, 2019
Surgical resection of head and neck (H and N) squamous cell carcinoma (SCC) may yield inadequate surgical cancer margins in 10 to 20% of cases. This study investigates the performance of label-free, reflectance-based hyperspectral imaging (HSI) and ...
M. Halicek, J. Dormer, James V. Little, Amy Y. Chen, L. Myers, B. Sumer, B. Fei   +6 more
semanticscholar   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Is wider surgical margin justified for better clinical outcomes in patients with resectable hepatocellular carcinoma?

Journal of the Formosan Medical Association, 2012
Surgical resection for hepatocellular carcinoma (HCC) is regarded as a curable treatment; however, the postoperative recurrence still poses a challenge to surgeons.
King-Teh Lee, Shen-Nien Wang, Rong-Wei Su, Hong-Yaw Chen, Hon-Yi Shi, Chen-Go Ker, Herng-Chia Chiu   +6 more
doaj   +1 more source

Impact of surgical margin status on the outcome of bladder cancer treated by radical cystectomy: a meta-analysis

OncoTarget, 2016
Data regarding the association between surgical margin status and the outcome of bladder cancer treated by radical cystectomy (RC) are conflicting. Therefore, the present meta-analysis was performed to assess the associations between the outcomes of ...
Xuwei Hong, Tieqiu Li, Fengsheng Ling, Dashan Yang, Li-na Hou, Fei Li, Wanlong Tan   +6 more
semanticscholar   +1 more source

Modeling postbreakup landscape development and denudational history across the southeast African (Drakensberg Escarpment) margin [PDF]

, 2002
We employ a numerical surface processes model to study the controls on postbreakup landscape development and denudational history of the southeast African margin.
Alastair Fleming, Braun, J., Brown, R. W., Fleming, A., van der Beek, P., Peter van der Beek, Roderick W. Brown, Michael A. Summerfield, Jean Braun, Summerfield, M. A.   +9 more
core   +1 more source