Results 161 to 170 of about 429,608 (293)

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

FEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr, Michael Fauler, Thomas Zimmer, Bettina Jungwirth, Hubert Schrezenmeier, David Alexander Christian Messerer   +5 more
wiley   +1 more source

Transition to robotic surgery in urologic oncology: a comparative analysis between pre-robotic and robotic eras in a high-volume tertiary center. [PDF]

J Robot Surg
Porreca A, Di Gianfrancesco L, De Marchi D, Simonetti F, Coppola M, Stefano A, Gallina P, Amodeo A, Franzoso G, Giuriola A, Bello SD, Marino F.   +11 more
europepmc   +1 more source

High LRIG1 expression predicts lymph node metastasis in patients with uterine cervical cancer

FEBS Open Bio, EarlyView.
Lymph node status is crucial in determining treatment for women with early‐stage cervical cancer. We demonstrate that high LRIG1 protein expression in primary tumors can predict lymph node metastases. Our findings support further investigation of LRIG1 as a biomarker to improve staging accuracy and guide treatment decisions in cervical cancer patients.
Pernilla Israelsson, Lisa Lif, Husam Oda, Alexandra Lorenzzi de Melo, David Lindquist, Håkan Hedman   +5 more
wiley   +1 more source

A Comparison of Operative Time Between Robotic Surgical Assistant (ROSA) and MAKO Robotic-Assisted Total Knee Arthroplasty: A Meta-Analysis. [PDF]

Cureus
Weissman B, Ma TY, Shen K, Chowdhury S, Speer D, Lambroussis C.   +5 more
europepmc   +1 more source

Teaching Python with team‐based learning: using cloud‐based notebooks for interactive coding education

FEBS Open Bio, EarlyView.
This study presents a novel approach to teaching Python and bioinformatics using team‐based learning and cloud‐hosted notebooks. By integrating interactive coding into biomedical education, the method improves accessibility, student engagement, and confidence—especially for those without a computing background.
Nuno S. Osório, Leonardo D. Garma
wiley   +1 more source

Management of Stone Disease in the Spina Bifida Patient. [PDF]

Curr Urol Rep
Davis MF, Yu KL, Srinivasan AK.
europepmc   +1 more source

Microbial profile of the appendix niche in acute appendicitis: a novel sampling approach

FEBS Open Bio, EarlyView.
This study utilized a novel sampling method, ERAT (i.e. endoscopic retrograde appendicitis treatment)‐guided lumen aspiration, to obtain samples from the appendix, and shotgun metagenomic sequencing was performed for in situ characterization of the appendix microbiome in patients with acute appendicitis.
Huimin Ma, Mingfei Wang, Yanhu Feng, Wanqi Zhang, Wenbo Wang, Yanfeng Xie, Guixiang Kong, Jie Feng, Pengfei Wang, Qi Wang, Xiaojun Huang   +10 more
wiley   +1 more source

Optimizing neurosurgical operating room schedule: Integrating machine learning models for operative time prediction and schedule design. [PDF]

Surg Neurol Int
Nathani KR, Machlab LA, von Kentzinsky HL, Feng E, Jayasuriya NM, Nathani AM, Ibrahim S, Bhandarkar A, Timm PC, Ali R, Tawk RG, Freedman B, Bydon M.   +12 more
europepmc   +1 more source

Structural and functional characterization of chitinase from carnivorous plant Drosera adelae

FEBS Open Bio, EarlyView.
A class I chitinase from the carnivorous plant Drosera adelae was expressed and purified using a yeast system, revealing high enzymatic activity. Structural analyses of the catalytic and chitin‐binding domains identified key tyrosine residues involved in substrate binding, offering insights into the enzyme's adaptation for insect digestion.
Kazunari Yoneda, Yuki Naruse, Yusaku Suizu, Tomohiro Araki, Yoshikazu Hoshi, Haruhiko Sakuraba, Junji Hayashi, Toshihisa Ohshima   +7 more
wiley   +1 more source

Post-Operative Pain Following Non-Surgical and Surgical Periodontal Procedures

, 2019
David G. Gillam, D Chatzopoulou
openaire   +4 more sources