Results 31 to 40 of about 3,908,518 (240)

Morphological Evaluation of Mitral Valve Based on Three-dimensional Printing Models: Potential Implication for Mitral Valve Repair

BIO Integration, 2021
Objective: This study aimed to analyze the morphological characteristics of rheumatic (RMVD) and degenerative mitral valve diseases (DMVD) based on three-dimensional (3D) printing model before and after surgery and to explore the potential implication of
Yuanting Yang, Hao Wang, Hongning Song, Yugang Hu, Qincheng Gong, Ye Xiong, Junbi Liu, Wei Ren, Qing Zhou   +8 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

A modular surgical simulator for microlaryngoscopy using standard instruments and the carbon dioxide laser

Laryngoscope Investigative Otolaryngology, 2022
Objective Build a microlaryngoscopy surgical simulator for endoscopic laryngeal surgery using standard microsurgical instruments and a CO2 laser. Study design Anatomical modeling, CAD design and 3D printed manufacturing. Subjects and methods We created a
Sara E. Bressler, Lacey K. Adkins, Michael E. Dunham, Rohan R. Walvekar, Jangwook P. Jung, Jorge A. Belgodere, Adam X. Bao, Lizabeth S. Breaux, Hunter C. Lee, Soheil Saneei, Austin P. Veal, John S. Carleton   +11 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Innovating surgical practice and policy: lessons learnt from the second Oxford Surgical Innovation Conference: Invited Editorial

, 2020
The section on changes in training from the Future in Surgery Report by the Royal College of Surgeons of England outlined key ideas for improving surgical training in the future.
Williams, Matthew, McVeigh, James, de Andres Crespo, Marta, Hoppe, Solveig, Handa, Ashok   +4 more
core   +1 more source

Validation of microvascular surgery simulation platform: pilot study in Paediatric Surgery training. [PDF]

, 2022
openIntroduzione L’utilizzo delle simulazioni nella formazione medica, in particolare chirurgica, è sempre più comune, vista la crescente richiesta di competenze specifiche.
DI LECCE, GIANNI
core  

Three-dimensional computer-assisted surgical simulation and intraoperative navigation in orthognathic surgery: A literature review

Journal of the Formosan Medical Association, 2015
By incorporating three-dimensional (3D) imaging and computer-aided design and manufacturing techniques, 3D computer-assisted technology has been applied widely to provide accurate guidance for assessment and treatment planning in clinical practice.
Hsiu-Hsia Lin, Lun-Jou Lo
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source