Results 41 to 50 of about 3,908,518 (240)
Presurgical Rehearsals for Patients Considering “Awake” Deep Brain Stimulation
Frontiers in Surgery, 2016 Simulated surgical environments are rapidly gaining adoption in training students, residents, and members of specailized surgical teams. However, minimal attention has been given to the use of simulated surgical environments to educate patients on ...
Ramsey Andrew Falconer +4 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Computer-Aided Surgical Simulation for Correcting Complex Limb Deformities in Children
Applied Sciences, 2020 This work aims to present an in-house low-cost computer-aided simulation (CASS) process that was recently implemented in the preoperative planning of complex osteotomies for limb deformities in children.
Leonardo Frizziero +10 more
doaj +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
BMC Medical EducationBackground The assessment of clinical reasoning in health trainees is vital yet poses challenges. We tracked the eye movements of participants while they were reviewing a neurological case with the goal of finding behavioral evidence to improve health ...
Lijun Sun, Yao Zhang, Bin Zheng
doaj +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
Challenges in evaluating surgical innovation [PDF]
, 2009 Research on surgical interventions is associated with several methodological and practical challenges of which few, if any, apply only to surgery. However, surgical evaluation is especially demanding because many of these challenges coincide.
Ergina, Patrick L +6 more
core +2 more sources
Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA
FEBS Open Bio, EarlyView.PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro +1 more
wiley +1 more source
Reto Surgical established in the year 1998, is an icon in the field of Surgical Instruments and Dental Instruments manufacturers and suppliers, with decades of rich and professional experience. We are extremely pleased to present this updated Catalogue
reto surgical
core +5 more sources
Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy
FEBS Open Bio, EarlyView.This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan +11 more
wiley +1 more source