Results 71 to 80 of about 515,032 (357)

Combined spatially resolved metabolomics and spatial transcriptomics reveal the mechanism of RACK1‐mediated fatty acid synthesis

open access: yesMolecular Oncology, EarlyView.
The authors analyzed the spatial distributions of gene and metabolite profiles in cervical cancer through spatial transcriptomic and spatially resolved metabolomic techniques. Pivotal genes and metabolites within these cases were then identified and validated.
Lixiu Xu   +3 more
wiley   +1 more source

Surgical Site Infection

open access: yes, 2020
Surgical site infections (SSIs) remain a significant source of postoperative morbidity throughout the world. Surgeons operating in resource-poor areas face the added challenges of patient malnutrition, inconsistent access to antimicrobials and underdeveloped patient and bacterial resistance surveillance systems. Nonetheless, adherence to sound surgical
Emmanuel A. Ameh   +3 more
openaire   +2 more sources

Targeting PRAME directly or via EZH2 inhibition overcomes retinoid resistance and represents a novel therapy for keratinocyte carcinoma

open access: yesMolecular Oncology, EarlyView.
The study evaluated the function and therapeutic implications of PRAME in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The findings demonstrate that PRAME impairs keratinocyte differentiation pathways. Furthermore, PRAME impairs anticancer response to retinoid compounds in BCC and SCC cells.
Brandon Ramchatesingh   +6 more
wiley   +1 more source

The European Hernia Society Prehabilitation Project: A Systematic Review of Intra-Operative Prevention Strategies for Surgical Site Occurrences in Ventral Hernia Surgery

open access: yesFrontiers in Surgery, 2022
BackgroundVentral hernia repair is one of the most commonly performed surgical procedures worldwide. To reduce the risk of complications, pre- and intra-operative strategies have received increasing focus in recent years.
D. Wouters   +10 more
doaj   +1 more source

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

open access: yesMolecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé   +7 more
wiley   +1 more source

Agent Based Virus Model using NetLogo: Infection Propagation, Precaution, Recovery, Multi-site Mobility and (Un)Lockdown [PDF]

open access: yesarXiv, 2021
This paper presents a novel virus propagation model using NetLogo. The model allows agents to move across multiple sites using different routes. Routes can be configured, enabled for mobility and (un)locked down independently. Similarly, locations can also be (un)locked down independently.
arxiv  

Dressings for the prevention of surgical site infection [PDF]

open access: yesCochrane Database of Systematic Reviews, 2011
Surgical wounds (incisions) heal by primary intention when the wound edges are brought together and secured, often with sutures, staples, or clips. Wound dressings applied after wound closure may provide physical support, protection and absorb exudate.
Dumville, Joanne   +9 more
openaire   +7 more sources

A Randomized Control Trial Comparing Transparent Film Dressings and Conventional Occlusive Dressings for Elective Surgical Procedures [PDF]

open access: yes, 2019
BACKGROUND: Surgical site infection is one of the major health-care-associated problems causing substantial morbidity and mortality and constituting a financial burden on hospitals as well.
Ahmed, Ahmed Nabil   +5 more
core   +2 more sources

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini   +10 more
wiley   +1 more source

The Effect of Duration of Disinfection of Bacterial Flora of Surgical Site

open access: yesنشریه پرستاری ایران, 2008
Background and Aim: Skin disinfection is an effective method of preventing surgical site infection (SSI), but there is controversy about the duration of skin preparation.
Mitra Zandiyeh   +4 more
doaj  

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